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. 2018 Nov 14;201(12):3717–3730. doi: 10.4049/jimmunol.1800987

FIGURE 4.

FIGURE 4.

The profiles of multiple cytokines. (A–C) IRI increased the local levels of IL-1β (A), IL-9 (B), and IL-12p40 (C) compared with Sham-operated mice, and these levels significantly declined in the indicated gene-deficient mice (left panel) and following CRIg/FH treatment compared with the PBS control (right panel). (D–H) IRI significantly reduced the local levels of IL-4 (D), IL-13 (E), and IL-10 (F) compared with Sham-operated mice and reduced IL-5 (G) and TNF-α (H) without significance; these factors were elevated in the indicated gene-deficient mice (left panel) and following CRIg/FH treatment compared with the PBS control (right panel). The error bars represent the mean ± SD (n = 5–8). ANOVA was performed among complement component deficiency mice, and t test was used between CRIg/FH and PBS-treated groups. *p < 0.05.