Table 1.
Characteristics of studies and lncRNA expression related to OS in GIC patients.
| References | lncRNAs (n = 105) | Year | Nations | Number (n = 12178) | OS | Cut-off value | Detection methods | Sample types | Follow-up | |
|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | |||||||||
| Sun et al. [13] | RNAGAS5↓ | 2014 | China | 89 GC | 2.43∗ | 1.29–4.59 | Median | RT-PCR | Tissue | <40 |
| Li et al. [29] | SNHG20↑ | 2016 | China | 107 CRC | 2.97∗ | 1.51–5.82 | YI | RT-PCR | Tissue | <40 |
| Kong et al. [15]! | PVT1↑ | 2015 | China | 80 GC | 2.09∗ | 1.07–4.10 | Median | RT-PCR | Tissue | <40 |
| Qi et al. [31] | AGAP2-AS1↑ | 2017 | China | 50 GC | 2.67# | 1.45–4.93 | Median | RT-PCR | Tissue | 6–36# |
| Chen et al. [32] | XIST↑ | 2016 | China | 106 GC | 3.11 | 1.67–3.78 | Median | RT-PCR | Tissue | <120 |
| Ye et al. [33] | lnc-GNAT1-1↓ | 2016 | China | 68 CRC | 2.16∗ | 1.01–4.63 | Median | RT-PCR | Tissue | <20 |
| Saito et al. [21] | ATB↑ | 2015 | Japan | 183 GC | 3.50∗ | 1.73–7.44 | Median | RT-PCR | Tissue | 0.192–134.4 |
| Yuan et al. [35]! | PVT1↑ | 2016 | China | 111 GC | 2.28∗ | 1.05–4.93 | Median | RT-PCR | Tissue | 20–48 |
| Ye et al. [36] | CLMAT3↑ | 2015 | China | 90 CRC | 2.05∗ | 1.10–3.82 | Dichotomize | RT-PCR | Tissue | <45 |
| Zheng et al. [37]! | UCA1↑ | 2015 | China | 112 GC | 2.35∗ | 1.22–4.52 | Dichotomize | RT-PCR | Tissue | <92 |
| Chen et al. [38] | NEAT1↑ | 2015 | China | 96 EC | 1.92∗ | 1.40–6.49 | YI | RT-PCR | Tissue | <80 |
| Wang et al. [39]! | CCAT2↑ | 2016 | China | 108 GC | 2.11∗ | 1.44–3.20 | Median | RT-PCR | Tissue | <70 |
| Zhao et al. [22] | HOTAIR↑ | 2015 | China | 168 GC | 1.47∗ | 1.04–2.06 | Median | RT-PCR | Tissue | <70 |
| Zhang et al. [40] | Sox2ot↑ | 2016 | China | 132 GC | 2.05∗ | 1.28–3.30 | Median | RT-PCR | Tissue | <96 |
| Chen et al. [41] | HIF1A-AS2↑ | 2015 | China | 83 GC | 1.72∗ | 1.00–2.96 | Median | RT-PCR | Tissue | <60 |
| Li et al. [10] | HOTAIR↑ | 2013 | China | 100 EC | 1.91 | 1.06–4.00 | 125-fold | RT-PCR | Tissue | <60 |
| Yue et al. [42]! | FER1L4↓ | 2015 | China | 70 CC | 3.99∗ | 1.67–9.01 | Median | RT-PCR | Tissue | <80 |
| He et al. [43] | CCAT1↑ | 2014 | China | 48 CC | 2.09# | 1.42–3.06 | Median | RT-PCR | Tissue | 24–37# |
| Yin et al. [44] | MEG3↓ | 2015 | China | 62 CRC | 0.13∗ | 0.02–0.99 | Mean | RT-PCR | Tissue | <60 |
| Nie et al. [45] | MIR31HG↓ | 2016 | China | 48 CC | 2.35# | 1.15–4.79 | Median | RT-PCR | Tissue | 3–36# |
| Park et al. [46] | BM742401↓ | 2013 | Korea | 113 GC | 1.03∗ | 0.57–1.88 | Median | RT-PCR | Tissue | <80 |
| Liu et al. [23] | CRNDE-h↑ | 2016 | China | 148 CRC | 2.39∗ | 1.30–4.39 | Median | RT-PCR | Serum | 1–65 |
| Li et al. [47] | PANDAR↑ | 2017 | China | 102 CRC | 3.08∗ | 0.84–7.89 | Median | RT-PCR | Tissue | <60 |
| Chen et al. [48]! | H19↑ | 2016 | China | 128 GC | 1.96∗ | 0.97–3.97 | Median | RT-PCR | Tissue | 20–48 |
| Zou et al. [49]! | Sox2ot↑ | 2016 | China | 155 GC | 3.24∗ | 1.24–6.43 | Median | RT-PCR | Tissue | <70 |
| Jiang et al. [50] | TUG1↑ | 2016 | China | 218 EC | 1.40∗ | 1.01–1.95 | NR | RT-PCR | Tissue | 12–72 |
| Svoboda et al. [51] | HOTAIR↑ | 2014 | Czech | 84 CRC | 5.9 | 1.34–26.1 | Median | RT-PCR | Blood | 12–54 |
| Wang et al. [52]! | OTUB1-isoform 2↑ | 2016 | China | 156 GC | 1.54 | 1.04–2.27 | Median | RT-PCR | Tissue | <80 |
| Guo et al. [53] | FTX↑ | 2015 | China | 187 CRC | 2.37 | 1.42–2.74 | Median | RT-PCR | Tissue | <60 |
| Pan et al. [54] | FOXCUT↑ | 2014 | China | 82 EC | 2.13# | 1.38–3.29 | Mean | RT-PCR | Tissue | 1–72 |
| Zhou et al. [55] | LET↓ | 2014 | China | 93 GC | 2.28 | 1.30–5.18 | Mean | RT-PCR | Tissue | <60 |
| Hu et al. [56] | linc-UBC1↑ | 2015 | China | 85 GC | 3.56# | 1.71–7.39 | Median | RT-PCR | Tissue | <100 |
| Wang et al. [57] | CCAT2↑ | 2015 | China | 86 GC | 2.41 | 1.19–5.42 | Mean | RT-PCR | Tissue | <60 |
| Ren et al. [58] | HOTTIP↑ | 2015 | China | 156 CRC | 2.15 | 1.31–3.42 | Median | RT-PCR | Tissue | 33–65 |
| Liu et al. [59]! | DANCR↑ | 2015 | China | 104 CRC | 2.13∗ | 1.16–7.06 | Median | RT-PCR | Tissue | <60 |
| Wang et al. [60]! | ZEB1-AS1↑ | 2015 | China | 87 EC | 2.37 | 1.28–6.12 | Median | RT-PCR | Tissue | <61 |
| Li et al. [61] | BANCR↑ | 2015 | China | 184 GC | 1.51∗ | 1.03–2.23 | Median | RT-PCR | Tissue | 5–93 |
| Ma [62]! | PANDAR↑ | 2016 | China | 100 GC | 3.68 | 1.13–12.06 | NR | RT-PCR | Tissue | 2–36 |
| Huang et al. [63] | MALAT1↑ | 2016 | China | 132 EC | 6.64 | 2.95–14.95 | NR | RT-PCR | Tissue | <60 |
| Ni et al. [64] | UCA1↑ | 2015 | China | 54 CRC | 3.11# | 0.59–16.39 | Median | RT-PCR | Tissue | 9–51# |
| Wu et al. [25] | uc002yug.2↑ | 2014 | China | 684 EC | 2.61 | 1.50–3.78 | NR | RT-PCR | Tissue | <140 |
| Sun et al. [16] | HOXA11-AS↑ | 2016 | China | 85 GC | 2.85# | 1.65–4.91 | Median | ISH | Tissue | 9–36 |
| Peng et al. [65]! | NEAT1↑ | 2016 | China | 56 CRC | 1.70# | 1.04–2.80 | NR | RT-PCR | Tissue | <60 |
| Jiao et al. [66] | UCA1↑ | 2016 | China | 66 EC | 2.24# | 1.17–4.29 | Median | RT-PCR | Tissue | 5–30# |
| Liu and Shangguan [67] | CARLo-5↑ | 2017 | China | 240 GC | 2.41∗ | 1.13–5.94 | 0.041 | RT-PCR | Tissue | <60 |
| Ma et al. [11] | CCAL↑ | 2016 | China | 252 CRC | 2.25∗ | 1.35–3.74 | Median | RT-PCR | Tissue | <100 |
| Yang et al. [18] | GHET1↑ | 2014 | China | 42 GC | 1.90# | 0.53–6.85 | Median | RT-PCR | Tissue | 7–40# |
| Wu et al. [68] | HOTAIR↑ | 2014 | China | 120 CC | 3.92 | 1.23–12.50 | 5-fold | RT-PCR | Tissue | 10–72 |
| Zhou et al. [69]! | ROR↑ | 2016 | China | 60 CC | 7.22∗ | 2.43–17.43 | Median | RT-PCR | Tissue | <80 |
| Yang et al. [70]! | Loc554202↓ | 2016 | China | 178 CRC | 2.45 | 1.34–7.74 | Median | RT-PCR | Tissue | <70 |
| Lü et al. [71] | BC032469↑ | 2016 | China | 58 GC | 2.78# | 0.95–8.09 | Mean | RT-PCR | Tissue | <23 |
| Su et al. [72] | BLACAT1↑ | 2017 | China | 48 CRC | 1.50∗ | 1.32–1.70 | Mean | RT-PCR | Tissue | <60 |
| Hu et al. [12] | GAPLINC↑ | 2014 | China | 90 GC | 1.54∗ | 1.22–1.94 | Median | ISH | Tissue | <80 |
| Fu et al. [73] | NEAT1↑ | 2016 | China | 140 GC | 1.61 | 1.03–2.53 | Median | RT-PCR | Tissue | <96 |
| Yao et al. [26] | RP11-766N7.4↓ | 2017 | China | 50 EC | 2.14# | 1.10–4.15 | Median | RT-PCR | Tissue | 32–60# |
| Xie et al. [74] | SPRY4-IT1↑ | 2014 | China | 92 EC | 2.05 | 1.04–4.03 | Median | RT-PCR | Tissue | 3–60 |
| Peng [75]! | SPRY4-IT1↑ | 2015 | China | 175 GC | 0.82∗ | 0.31–1.57 | Median | RT-PCR | Tissue | <60 |
| Nie et al. [76]! | ZFAS1↑ | 2016 | China | 54 GC | 2.08# | 1.11–3.93 | Median | RT-PCR | Tissue | 3–36# |
| Ohtsuka et al. [77] | H19↑ | 2016 | USA | 117 CC | 1.28∗ | 1.08–1.50 | 0.64 | RT-PCR | Tissue | <90 |
| Li et al. [20] | MALAT1↑ | 2017 | China | 68 CRC | 2.17# | 1.32–3.55 | Median | RT-PCR | Tissue | 1–51# |
| Zhou et al. [78] | AFAP1-AS1↑ | 2016 | China | 162 EC | 1.89∗ | 1.22–2.92 | Median | RT-PCR | Tissue | 6–72 |
| Sun et al. [80]! | RP11-119F7.4↓ | 2015 | China | 96 GC | 1.20# | 0.84–1.71 | Median | RT-PCR | Tissue | <100 |
| Zhang et al. [81]! | ANRIL↑ | 2014 | China | 120 GC | 1.74∗ | 1.04–2.93 | 3-fold | RT-PCR | Tissue | <60 |
| Li et al. [82]! | NEAT1↑ | 2015 | China | 239 CRC | 1.70∗ | 1.18–2.45 | 2-fold | RT-PCR | Tissue | <60 |
| Chen et al. [83] | LINC00152↑ | 2016 | China | 97 GC | 1.66∗ | 1.01-2.73 | Median | RT-PCR | Tissue | <60 |
| Chen et al. [19] | FEZF1-AS1↑ | 2016 | China | 153 CRC | 2.40∗ | 1.07–5.41 | NR | ISH | Tissue | <100 |
| Han et al. [84]! | H19↑ | 2016 | China | 83 CRC | 1.43∗ | 1.24–1.79 | 3-fold | RT-PCR | Tissue | <50 |
| Yang et al. [85] | GAPLINC↑ | 2016 | China | 180 CRC | 2.21∗ | 1.38–3.57 | NR | ISH | Tissue | <100 |
| Jin et al. [86] | HULC↑ | 2016 | China | 54 GC | 1.92# | 1.00–3.67 | 2-fold | RT-PCR | Serum | 11–32# |
| Cao et al. [87]! | BC200↑ | 2016 | China | 70 EC | 2.24∗ | 1.12–4.49 | Median | RT-PCR | Tissue | <50 |
| Cao et al. [88] | SPRY4-IT1↑ | 2016 | China | 84 CRC | 3.21∗ | 1.55–6.67 | 2.87-fold | RT-PCR | Tissue | 3–36 |
| Gao et al. [89] | linc-UBC1↑ | 2017 | China | 96 CRC | 2.43∗ | 1.09–5.42 | Median | RT-PCR | Tissue | <60 |
| Wang et al. [90]! | AFAP1-AS1↑ | 2016 | China | 52 CRC | 2.36 | 1.11–5.01 | Median | RT-PCR | Tissue | <50 |
| Ge et al. [91] | PCAT-1↑ | 2013 | China | 108 CRC | 3.12 | 1.36–7.19 | NR | RT-PCR | Tissue | <100 |
| Deng et al. [92] | 91H↑ | 2014 | China | 72 CRC | 3.66 | 1.66–8.10 | 2.86-fold | RT-PCR | Tissue | 2–36 |
| Sun et al. [93]! | AK098081↑ | 2016 | China | 84 CRC | 1.90∗ | 1.39–2.58 | Mean | RT-PCR | Tissue | 1–118# |
| Xu et al. [94]! | FENDRR↓ | 2014 | China | 158 GC | 1.76 | 1.04–3.12 | Median | RT-PCR | Tissue | 20–48 |
| Bian et al. [96] | UCA1↑ | 2016 | China | 90 CRC | 2.40∗ | 1.04-5.50 | Median | RT-PCR | Tissue | <100 |
| Zuo et al. [97] | UCA1↑ | 2017 | China | 37 GC | 2.92∗ | 1.07–7.96 | Median | RT-PCR | Tissue | <40 |
| Lu et al. [98] | PANDAR↑ | 2017 | China | 124 CRC | 3.53∗ | 1.41–4.45 | Median | RT-PCR | Tissue | <60 |
| Lv et al. [99] | MEG3↓ | 2016 | China | 96 EC | 2.12 | 1.05–4.27 | NR | RT-PCR | Tissue | <120 |
| Xu et al. [100] | TUSC7↓ | 2017 | China | 63 CRC | 2.92 | 1.03–8.33 | NR | RT-PCR | Tissue | <120 |
| Ma et al. [101] | DUXAP8↑ | 2016 | China | 72 GC | 2.37# | 1.39–4.05 | Median | RT-PCR | Tissue | 5–36# |
| Fei et al. [103]! | LINC00982↓ | 2016 | China | 106 GC | 2.87∗ | 1.34–6.17 | Median | RT-PCR | Tissue | 20–48 |
| Chen et al. [104]! | SNHG15↑ | 2016 | China | 106 GC | 2.93∗ | 1.30–6.58 | Median | RT-PCR | Tissue | 20–48 |
| Tan et al. [105] | SPRY4-IT1↑ | 2017 | China | 106 CRC | 2.34∗ | 1.14–4.83 | Mean | RT-PCR | Tissue | <70 |
| Wang and Xing [106] | ZFAS1↑ | 2016 | China | 159 CRC | 1.88∗ | 1.01–3.53 | Median | RT-PCR | Tissue | <101 |
| Yao et al. [107] | MALAT-1↑ | 2016 | China | 137 EC | 1.27# | 0.90–1.80 | 0.5-fold | RT-PCR | Tissue | 3–36# |
| Liu et al. [108]! | BANCR↑ | 2016 | China | 142 EC | 0.95∗ | 0.21–0.95 | Median | RT-PCR | Tissue | 1–60# |
| Chen et al. [109] | HOTAIR↑ | 2013 | China | 78 EC | 2.40∗ | 1.35–4.28 | Mean | RT-PCR | Tissue | 2–60 |
| Hu et al. [102]a | Linc00152↑ | 2016 | China | 205 EC | 1.89 | 1.22–2.58 | Upper 95% CI in control group | RT-PCR | Plasma | <60 |
| POU3F3↑ | 1.82 | 1.17–2.51 | ||||||||
| CFLAR↑ | 1.68 | 1.08–2.32 | ||||||||
| Yu et al. [110] | u50535↑ | 2018 | China | 98CRC | 4.01∗ | 1.06–15.14 | NR | RT-PCR | Tissue | <60 |
| Jiang et al. [111] | CRNDE↑ | 2017 | China | 251CRC | 1.69∗ | 1.05–2.74 | NR | ISH | Tissue | 1–117 |
| Cui et al. [112] | HEIH↑ | 2018 | China | 84CRC | 1.46∗ | 1.02–2.08 | Median | RT-PCR | Tissue | <60 |
| Wu et al. [113]! | GHRLOS↓ | 2017 | China | 366CRC | 1.96∗ | 1.34–2.86 | 1/2-fold | RT-PCR | Tissue | 5–85 |
| Li et al. [115] | ZEB1-AS1↑ | 2017 | China | 24GC | 2.36∗ | 1.41–3.96 | Median | RT-PCR | Tissue | 72 |
| Huang et al. [116] | LINC00673↑ | 2017 | China | 73GC | 2.38∗ | 1.12–5.06 | 2-fold | RT-PCR | Tissue | <20 |
| Li et al. [117] | PVT1↑ | 2017 | China | 104ESCC | 2.75∗ | 1.35–5.59 | Median | RT-PCR | Tissue | <80 |
| Shi et al. [118] | ZFAS1↑ | 2017 | China | 246ESCC | 1.59∗ | 1.07–2.36 | Median | RT-PCR | Tissue | 114 |
| Wu et al. [119] | XIST↑ | 2017 | China | 127ESCC | 2.4∗ | 1.44–4.01 | Median | RT-PCR | Tissue | <80 |
| Ba et al. [120] | LINC00673↑ | 2017 | China | 79GC | 2.56∗ | 1.01–4.54 | Median | RT-PCR | Tissue | <50 |
| Zhu et al. [121] | SNHG1↑ | 2017 | China | 108CRC | 3.17∗ | 1.55–6.21 | Median | RT-PCR | Tissue | <50 |
| Yang et al. [122] | LINC01133↓ | 2018 | China | 149ESCC | 2.18∗ | 1.23–3.85 | Median | RT-PCR | Tissue | <60 |
aOne study involved lncRNA Linc00152, lncRNA POU3F3, and lncRNA CFLAR. ∗ indicates adjusted HR; # indicates calculated HR of OS and follow-up time; ! indicates studies included OS and DFS; ↑ or ↓ indicates upregulated or downregulated with poor prognosis. OS: overall survival; DFS: disease-free survival; HR: hazard ratio; CI: confidence interval; EC: esophageal cancer; GC: gastric cancer; CRC: colorectal cancer; GIC: gastrointestinal cancer; NR: no report; YI: Youden index; RT-PCR: reverse transcription PCR; ISH: in situ hybridization.