Table 3.
lncRNAs and relevant targets in gastrointestinal cancer.
| lncRNAs (n = 37) | Poor prognosis | Role | Relevant targets | Function | Reference |
|---|---|---|---|---|---|
| SNHG20↑ | Upregulated | Oncogene | Cyclin A1, p21 | Proliferation/invasion/migration | [29] |
| PVT1↑ | Upregulated | Oncogene | EZH2, p15, p16, FOXM1 | Proliferation/metastasis | [15, 34] |
| FEZF1-AS1↑ | Upregulated | Oncogene | LSD1, P21, FEZF1 | Proliferation/invasion/migration | [17, 19] |
| AGAP2-AS1↑ | Upregulated | Oncogene | LSD1, EZH2, P21, E-cadherin | Proliferation/migration/invasion | [31] |
| XIST↑ | Upregulated | Oncogene | miR-101, EZH2 | Proliferation/migration/invasion/growth/metastasis | [32] |
| ATB↑ | Upregulated | Oncogene | miR-200s, ZEB1, ZEB2 | Invasion/EMT | [21] |
| UCA1↑ | Upregulated | Oncogene | Ets-2, Sox4, miR-204, miR-204-5p, TGFβ1 | Migration/invasion/proliferation/apoptosis/chemoresistance/EMT | [64, 66, 96, 97] |
| NEAT1↑ | Upregulated | Oncogene | Akt, vimentin, N-cadherin, Zo-1, E-cadherin | Proliferation/apoptosis/EMT/migration/invasion | [65, 73] |
| CCAT2↑ | Upregulated | Oncogene | EZH2, E-cadherin, LATS2 | Progression | [39] |
| CCAT1↑ | Upregulated | Oncogene | c-Myc | Proliferation/migration/invasion | [43] |
| PANDAR↑ | Upregulated | Oncogene | N-cadherin, vimentin, β-catenin, Snail, Twist, E-cadherin | EMT/growth/migration/invasion/apoptosis | [98] |
| H19↑ | Upregulated | Oncogene | E-cadherin, Rb-E2F, CDK8, β-catenin, eIF4A3 | Migration/invasion/proliferation | [48, 77, 84] |
| FOXCUT↑ | Upregulated | Oncogene | FOXC1 (mRNA) | Proliferation/migration/invasion | [54] |
| MALAT1↑ | Upregulated | Oncogene | EZH2, miR-218 | Chemoresistance/EMT | [20] |
| uc002yug.2↑ | Upregulated | Oncogene | RUNX1 | Proliferation/migration/invasion | [25] |
| HOXA11-AS↑ | Upregulated | Oncogene | EZH2, LSD1, miR-1297 | Growth/migration/invasion/apoptosis | [16] |
| CCAL↑ | Upregulated | Oncogene | AP-2α | Progression/multidrug resistance | [11] |
| GHET1↑ | Upregulated | Oncogene | c-Myc (mRNA) | Proliferation | [18] |
| ROR↑ | Upregulated | Oncogene | miR-145 | Proliferation/migration/invasion | [69] |
| BC032469↑ | Upregulated | Oncogene | miR-1207-5p | Proliferation | [71] |
| BLACAT1↑ | Upregulated | Oncogene | EZH2, p15 | Proliferation | [72] |
| GAPLINC↑ | Upregulated | Oncogene | miR211-3p, CD44, PSF, NONO, SNAI2 | Invasion | [12, 85] |
| SPRY4-IT1↑ | Upregulated | Oncogene | Cyclin D1, MMP2, MMP9, E-cadherin, vimentin | Proliferation/migration/invasion/EMT/metastasis | [75, 88] |
| ZFAS1↑ | Upregulated | Oncogene | EZH2, LSD1, CoREST, KLF2, NKD2 | Proliferation | [76] |
| ANRIL↑ | Upregulated | Oncogene | PRC2, miR-99a, miR-449a | Proliferation | [81] |
| LINC00152↑ | Upregulated | Oncogene | EZH2, p15, p21 | Proliferation | [83] |
| DUXAP8↑ | Upregulated | Oncogene | EZH2, SUZ12, PLEKHO1 | Proliferation/migration | [101] |
| SNHG15↑ | Upregulated | Oncogene | MMP2, MMP9 | Proliferation/migration/invasion | [104] |
| GAS5↓ | Downregulated | Suppressor | E2F1, P21 | Proliferation | [13] |
| lnc-GNAT1-1↓ | Downregulated | Suppressor | RKIP-NF-κB-Snail | Proliferation/migration/invasion/metastasis | [33] |
| FER1L4↓ | Downregulated | Suppressor | miR-106a-5p | Proliferation/migration/invasion | [42] |
| MEG3↓ | Downregulated | Suppressor | p53 | Proliferation/apoptosis | [99] |
| MIR31HG↓ | Downregulated | Suppressor | E2F1, P21 | Proliferation | [45] |
| RP11-766N7.4↓ | Downregulated | Suppressor | Vimentin, N-cadherin, E-cadherin | Migration/invasion/EMT | [26] |
| FENDRR↓ | Downregulated | Suppressor | FN1, MMP2, MMP9 | Migration/invasion | [94] |
| TUSC7↓ | Downregulated | Suppressor | miR-211-3p | Proliferation | [100] |
| LINC00982↓ | Downregulated | Suppressor | P15, P16 | Proliferation | [103] |