Figure 1.

mRNA expression of cathepsins K and X in gliomas of different grades and GBM subtypes. Public transcriptomic datasets were used as described in Materials and methods. Higher cathepsin K and X mRNA expression was found in GBM (grade IV glioma) versus grade II and III glioma (A, D), in GBM versus normal brain (B, E), and in the mesenchymal subtype of GBM versus the classical, proneural and neural subtypes, as classified according to Verhaak et al.³⁹ (C, F). Boxplots show the distribution of mRNA expression (log2) in glioma grade II and III and GBM. Data were retrieved from GlioVis portal.³⁷ The significance was set at p < 0.01 (**), p < 0.001 (***).