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Potency of natural bile acids for FXR biding (modified according to Gioiello et al., 2014).
| Bile acid species | Free carboxylic acid | Glycine conjugated bile salt | Taurine conjugated bile salt |
|---|---|---|---|
| CDCA (primary) | 4.5 μM | 10 μM | 10 μM |
| CA (primary) | >100 μM | >100 μM | >100 μM |
| LCA (secondary) | 3.8 μM | 4.7 μM | 3.8 μM |
| DCA (secondary) | 100 μM | >100 μM | >100 μM |
| UDCA (secondary) | >100 μM | >100 μM | >100 μM |
