Table 2.
Analysis of regional response to transient negative images as predictors of residual CAPS-vigilance scores
| A priori anatomical ROIs | ABM (n=41) | Sham (n=21) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Region | Brod-mann’s areas | Location of centroid voxel | x | y | z | Cluster extent (voxels) | r/R2 (unbiased) | p | r/R2 (unbiased) | p |
| L amygdala | – | L amygdala | −23 | −3 | −24 | 79 | r=−.34; R2=.116 | .032 | r=.07; R2=.005 | .78 |
| R amygdala | – | R amygdala | 26 | −1 | −22 | 77 | r=−.48; R2=.230 | .001 | r=.13; R2=.017 | .59 |
| L BNST | – | L BNST | −8 | 0 | 0 | 10 | r=−.42; R2=.176 | .007 | r=−.11; R2=.012 | .63 |
| R BNST | – | R BNST | 9 | 1 | 2 | 17 | r=−.33; R2=.109 | .036 | r=−.06; R2=.004 | .79 |
| dACC | 32, 24 | R anterior cingulate | 3 | 16 | 31 | 522 | r=−.53; R2=.281 | <.001 | r=−.03; R2=.001 | .92 |
| pgACC | 32, 24 | R anterior cingulate | 2 | 34 | 4 | 377 | r=−.42; R2=.176 | .006 | r=.06; R2=.004 | .80 |
| sgACC | 24, 25 | L anterior cingulate | 0 | 27 | 0 | 61 | r=−.10; R2=.010 | .54 | r=−.09; R2=.008 | .71 |
| VMPFC | 10, 11, 32 | R medial frontal gyrus | 2 | 48 | −4 | 507 | r=−.41; R2=.168 | .007 | r=.24; R2=.058 | .30 |
| L VLPFC | 47, 11 | L inferior frontal gyrus | −37 | 27 | −11 | 458 | r=−.48; R2=.230 | .002 | r=.10; R2=.010 | .68 |
| VLPFC | 47, 11 | R inferior frontal gyrus | 42 | 28 | −11 | 466 | r=−.49; R2=.240 | .001 | r=.25; R2=.063 | .28 |
| L DLPFC | 9, 46 | L middle frontal gyrus | −33 | 29 | 39 | 793 | r=−.38; R2=.144 | .015 | r=.12; R2=.014 | .61 |
| R DLPFC | 9, 46 | R middle frontal gyrus | 32 | 29 | 39 | 771 | r=−.37; R2=.137 | .017 | r=.08; R2=.006 | .73 |
| Whole-brain analysis | ABM (n=41) | Sham (n=21) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Region | Brod-mann’s areas | Location of centroid voxel | x | y | z | Cluster extent (voxels) | r/R2 (post hoc) |
p | r/R2 (post hoc) |
p |
| dACC/dmPFC | 32, 8, 6 | R medial frontal gyrus | 1 | 12 | 48 | 113 | r=−.61; R2=.372 | <.001 | r=.08; R2=.006 | .74 |
| L ventral postcentral gyrus/insula | 43, 13, 3 | L postcentral gyrus | −57 | −17 | 17 | 111 | r=−.67; R2=.449 | <.001 | r=−.11; R2=.012 | .63 |
| R VLPFC | 47, 13 | R inferior frontal gyrus | 38 | 13 | −19 | 86 | r=−.68; R2=.462 | <.001 | r=.05; R2=.003 | .84 |
| R DLPFC | 6, 8 | R middle frontal gyrus | 45 | 7 | 51 | 72 | r=−.64; R2=.410 | <.001 | r=−.06; R2=.004 | .80 |
| R middle/superior temporal cortex | 21, 22 | R middle temporal gyrus | 54 | −5 | −17 | 58 | r=−.61; R2=.372 | <.001 | r=.00; R2=.000 | .99 |
| L dorsal postcentral gyrus | 2, 1 | L postcentral gyrus | −52 | −30 | 51 | 50 | r=−.60; R2=.360 | <.001 | r=.25; R2=.063 | .27 |
| R insula/IFG | 44, 13 | R insula | 49 | 10 | 5 | 41 | r=−.60; R2=.360 | <.001 | r=.06; R2=.004 | .81 |
| pgACC | 32, 9 | R anterior cingulate cortex | 5 | 38 | 18 | 40 | r=−.59; R2=.348 | <.001 | r=.07; R2=.005 | .77 |
| R thalamus | – | R thalamus | 8 | −18 | 15 | 35 | r=−.60; R2=.360 | <.001 | r=−.08; R2=.006 | .72 |
| R amygdala/hippocampus | 34 | R amygdala | 17 | −4 | −25 | 33 | r=−.65; R2=.423 | <.001 | r=−.10; R2=.010 | .66 |
| L DLPFC | 6 | L precentral gyrus | −51 | −5 | 49 | 31 | r=−.63; R2=.397 | <.001 | r=.04; R2=.002 | .87 |
| L Precentral Gyrus | 6, 22 | L precentral gyrus | −56 | 0 | 6 | 29 | r=−.61; R2=.372 | <.001 | r=.04; R2=.002 | .88 |
Note: Coordinates for each cluster’s center-of-mass are presented in MNI space. Unrestricted whole brain analysis findings have voxel-wise error rate p < .001; map-wise error rate p < .05, except for italicized regions which have map-wise p < .10. “Post hoc” effect sizes from whole brain search are likely to be inflated (e.g., see Vul et al, 2009). Bolded text indicates p<.05 for a priori anatomical ROIs. dACC=dorsal anterior cingulate cortex; VLPFC= ventrolateral prefrontal cortex; DLPFC=dorsolateral prefrontal cortex; IFG=inferior frontal gyrus; pgACC=perigenual anterior cingulate cortex.