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. 2018 Dec 10;17:462. doi: 10.1186/s12936-018-2598-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Screening cascade for identifying compounds for TCP-6 or ATSB. The bottom box identifies the suite of studies necessary for full evaluation of a potential TCP-6 candidate drug. If any properties require optimization, then medicinal chemistry would be driven using the A. stephensi SMFA to assess potency alongside any of the other relevant non-efficacy assays