Table 2.

Guidelines on the use of aspirin in primary prevention

Organization (year)	Recommendation	Class (level of evidence)
ACCP (2012) (15)	Low-dose aspirin (75–100 mg/day) in patients >50 years of age over no aspirin therapy.	II (B)
ESC/EASD (2013) (18)	Antiplatelet therapy with aspirin in patients with DM at low CVD risk is not recommended.	III (A)
ESC/EASD (2013) (18)	Antiplatelet therapy for primary prevention may be considered in high risk patients with DM on an individual basis.	IIb (C)
AHA/ADA (2015) (19)	Low-dose aspirin (75–162 mg/day) is reasonable among those with a 10-year CVD risk of at least 10% and without an increased risk of bleeding.	IIa (B)
AHA/ADA (2015) (19)	Low-dose aspirin is reasonable in adults with DM at intermediate risk (10-year CVD risk, 5%–10%).	IIb (C)
ESC (2016) (14)	Aspirin is not recommended in individuals without CVD due to the increased risk of major bleeding.	III (B)
USPSTF (2016) (17)	The USPSTF guidelines recommend initiating low-dose aspirin use for the primary prevention of CVD and CRC in adults aged 50 to 59 years who have a 10% or greater 10-year CVD risk, are not at increased risk for bleeding, have a life expectancy of at least 10 year, and are willing to take low- dose aspirin daily for at least 10 years.	B
USPSTF (2016) (17)	The decision to initiate low-dose aspirin use for the primary prevention of CVD and CRC in adults aged 60 to 69 yrs of age who have a 10% or greater 10-yr CVD risk should be an individual one. Persons who are not at increased risk for bleeding, have a life expectancy of at least 10 years, and are willing to take low-dose aspirin daily for at least 10 years are more likely to benefit. Persons who place a higher value on the potential benefits than the potential harms may choose to initiate low-dose aspirin.	C

CRC - colorectal cancer; CVD - cardiovascular disease; DM - diabetes mellitus; USPSTF - United States Preventive Services Task Force