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PAI‐1 is induced in murine dietary models of NASH. (A) Plasma level of PAI‐1 (ng/mL) and (B) hepatic mRNA level of Pai‐1 in wild‐type Pai‐1+/+ mice fed an MCD diet or MCS diet for 8 weeks. (C) Plasma level of PAI‐1 (ng/mL) and (D) hepatic mRNA level of Pai‐1 in wild‐type Pai‐1+/+ mice fed an HFHS diet or SFD for 16 weeks. Values are expressed as mean ± SD; n = 8; *P < 0.05 versus respective control diet. Abbreviation: mRNA, messenger RNA.
