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. 2018 Sep 26;2(12):1479–1492. doi: 10.1002/hep4.1259

Figure 3.

Figure 3

Pai‐1 deletion does not prevent HFHS diet‐induced hepatic inflammation or fibrosis. (A) Body weight change (%), (B) H&E‐stained liver sections, (C) steatosis grade, (D) hepatic triglyceride content (mg/g liver), (E) number of inflammatory foci on H&E sections per hpf, (F) plasma ALT (U/L), (G) F4/80‐stained liver sections with quantification (# cells/100 hepatocytes), (H) Masson’s trichrome‐stained liver sections with quantification of trichrome staining, (I) hepatic hydroxyproline content (µg/g protein), and (J) hepatic level of active tPA (ng/g liver) in Pai‐1 –/– and Pai‐1+/+ mice fed an HFHS diet or SFD for 16 weeks. Values are expressed as mean ± SD; n = 6‐9; *P < 0.05. Abbreviations: KO, knockout; WT, wild type.