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. 2018 Sep 26;2(12):1479–1492. doi: 10.1002/hep4.1259

Figure 4.

Figure 4

Pharmacologic inhibition of PAI‐1 attenuates MCD diet‐induced hepatic steatosis but does not prevent hepatic fibrosis. (A) Plasma level of active PAI‐1 (ng/mL), (B) H&E‐stained liver sections, (C) steatosis grade, (D) hepatic triglyceride content (mg/g liver), (E) number of inflammatory foci on H&E sections per hpf, (F) plasma ALT (U/L), (G) F4/80‐stained liver sections with quantification (# cells/100 hepatocytes), (H) Masson’s trichrome‐stained liver sections with quantification of trichrome staining, (I) hepatic hydroxyproline content (µg/g protein), and (J) hepatic level of active tPA (ng/g liver) in C57BL/6J mice fed an MCD or MCS diet with or without TM5441 for 8 weeks. Values are expressed as mean ± SD; n = 8; *P < 0.05.