Table 1.
Hepatic Gene Expression in PAI‐1–/– and PAI‐1+/+ Mice Fed an MCD or MCS Diet for 8 Weeks
| MCS | MCD | ||||
|---|---|---|---|---|---|
| Pai‐1 +/+ | Pai‐1 –/– | Pai‐1 +/+ | Pai‐1 –/– | ||
| Triglyceride synthesis | Srebp‐1c | 1.1 ± 0.5 | 1.2 ± 0.7 | 1.0 ± 0.5 | 1.1 ± 0.7 |
| Fas | 1.0 ± 0.4 | 1.0 ± 0.3 | 0.4* ± 0.3 | 0.4* ± 0.2 | |
| Acc | 1.1 ± 0.5 | 0.6 ± 0.3 | 1.1 ± 0.5 | 0.8 ± 0.1 | |
| Fatty acid oxidation | Pparα | 1.0 ± 0.4 | 1.5 ± 1.0 | 0.9 ± 0.4 | 2.7*, † ± 1.5 |
| Pgc1α | 1.0 ± 0.2 | 1.2 ± 0.2 | 2.1* ± 0.5 | 4.5*, † ± 1.5 | |
| Aco | 1.1 ± 0.6 | 1.6 ± 0.5 | 0.9 ± 0.3 | 1.2 ± 0.5 | |
| Cpt1α | 1.0 ± 0.2 | 1.0 ± 0.2 | 0.8 ± 0.1 | 1.1 ± 0.4 | |
| Hepatic inflammation | Tnfα | 1.1 ± 0.4 | 1.1 ± 0.4 | 4.6* ± 1.3 | 3.6* ± 1.5 |
| Mcp‐1 | 1.1 ± 0.7 | 1.5 ± 0.4 | 9.1* ± 4.4 | 19.0* ± 10.0 | |
| Mip1α | 1.1 ± 0.6 | 1.3 ± 0.6 | 13.8* ± 6.1 | 19.6* ± 10.2 | |
| Hepatic fibrosis | Timp‐1 | 1.1 ± 0.8 | 1.7 ± 1.0 | 14.3* ± 5.0 | 14.9* ± 4.8 |
| Col1α1 | 1.5 ± 1.0 | 1.5 ± 0.8 | 6.8* ± 2.7 | 7.0* ± 2.8 | |
Relative expression, mean ± SD.
*
P < 0.05 versus MCS‐fed mice of the same genotype;
†
P < 0.05 versus Pai‐1 +/+ mice fed the same diet.