Table 4.
Hepatic Gene Expression in C57BL/6J Mice Fed an HFHS Diet or SFD With or Without TM5441 for 8 or 16 Weeks
| SFD | HFHS × 8 Weeks | HFHS × 16 Weeks | |||||
|---|---|---|---|---|---|---|---|
| –TM5441 | +TM5441 | –TM5441 | +TM5441 | –TM5441 | +TM5441 | ||
| Triglyceride synthesis | Srebp‐1c | 1.1 ± 0.4 | 0.5 † ± 0.4 | 2.5* ± 0.6 | 0.9 † ± 0.7 | 2.8* ± 0.8 | 2.5* ± 0.8 |
| Fas | 1.2 ± 0.8 | 0.5 † ± 0.2 | 0.8 ± 0.2 | 0.3 † ± 0.2 | 1.3 ± 0.5 | 1.0 ± 0.2 | |
| Acc | 1.0 ± 0.3 | 0.6 † ± 0.1 | 0.6 ± 0.2 | 0.6 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.1 | |
| Fatty acid oxidation | Pparα | 1.0 ± 0.2 | 1.6 ± 0.4 | 2.0* ± 0.8 | 0.9 ± 0.5 | 0.8 ± 0.2 | 3.5*, † ± 2.1 |
| Pgc1α | 1.1 ± 0.5 | 0.9 ± 0.1 | 0.5* ± 0.1 | 0.4* ± 0.3 | 0.3* ± 0.2 | 0.5* ± 0.2 | |
| Aco | 1.0 ± 0.2 | 1.6 † ± 0.3 | 1.0 ± 0.4 | 1.1 ± 0.8 | 0.6* ± 0.2 | 0.9 ± 0.3 | |
| Cpt1α | 1.0 ± 0.1 | 1.6 † ± 0.2 | 1.2 ± 0.2 | 1.1 ± 0.5 | 1.8 ± 0.6 | 1.0 ± 0.1 | |
| Hepatic inflammation | Tnfα | 1.0 ± 0.3 | 1.2 ± 0.6 | 1.7* ± 0.7 | 0.6 ± 0.5 | 0.6 ± 0.2 | 1.0 ± 0.2 |
| Mcp‐1 | 1.0 ± 0.4 | 2.1 ± 1.8 | 2.6* ± 0.6 | 5.3*, † ± 4.1 | 4.6* ± 3.9 | 2.6* ± 1.5 | |
| Mip1α | 1.1 ± 0.5 | 1.8 ± 0.6 | 1.1 ± 0.2 | 1.2 ± 0.3 | 3.2* ± 2.3 | 2.1* ± 1.3 | |
| Hepatic fibrosis | Timp‐1 | 1.2 ± 1.0 | 0.7 ± 0.2 | 5.4* ± 2.0 | 2.6*, † ± 0.8 | 5.3* ± 1.9 | 4.4* ± 0.8 |
| Col1α1 | 1.1 ± 0.5 | 0.3 † ± 0.1 | 2.1* ± 0.8 | 0.7 † ± 0.5 | 1.8* ± 1.0 | 2.5* ± 1.1 | |
Relative expression, mean ± SD.
*
P < 0.05 versus SFD‐fed mice with the same drug exposure (+/–TM5441);
†
P < 0.05 versus nondrug‐treated mice (–TM5441) fed the same diet.