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. 2018 Oct 29;2(12):1513–1532. doi: 10.1002/hep4.1270

Figure 6.

Figure 6

OCA treatment reduces hepatic fibrosis in 34‐week HFD‐fed Ldlr‐/‐.Leiden mice. Mice were treated with OCA (10 mg/kg/day) from t = 24 weeks to t = 34 weeks. (A) Picrosirius red–stained liver cross‐sections showing reduced fibrosis in OCA‐treated mice. (B) Pathologist’s assessment of perihepatocellular fibrosis revealed reduced progression of fibrosis in HFD+OCA. (C) Biochemically determined hepatic collagen was reduced in HFD+OCA. OCA reduced the collagen area and degree of reticulation of thin‐fiber collagen (D) and aggregated‐fiber collagen (E) (multiphoton and SHG imaging). Data are mean ± SD. *P < 0.05; **P < 0.01 versus HFD at 34 weeks.