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OCA treatment reduces de novo collagen synthesis in 34‐week HFD‐fed Ldlr‐/‐.Leiden mice. Mice were treated with OCA (10 mg/kg/day) from t = 24 weeks to t = 34 weeks. (A) OCA reduced de novo total collagen synthesis assessed by stable‐isotope labeling and in parallel reduced de novo synthesis of individual collagen chains in the guanidine‐insoluble (B) and guanidine‐soluble (C) fractions. Data are mean ± SD. *P < 0.05; **P < 0.01 versus HFD at 34 weeks.
