Figure 2 ∣. Crystal structure of automethylated Clr4^192−490 reveals a conformational switch.

a, Crystal structure of automethylated Clr4^192−490 with bound SAM. See Fig. 1g legend for details. b, Expanded view of the active site showing that auto-methylation (right) results in a conformational switch that creates an open catalytic pocket and stabilization of SET-I residues 371–379 which are disordered in the autoinhibited conformation (left). See Extended Data Fig. 4a and b for surface presentations.