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. 2018 Dec 5;13:8165–8178. doi: 10.2147/IJN.S182998

Figure 2.

Figure 2

The effects of different concentrations of SVNs and SV on MG63 cells.

Notes: When the dosing concentration was 0.25 and 0.025 μmol/L, the effects of SVNs and SV on the cellular proliferation activity (A) and ALP activity were determined (D). When the dosing concentration was 2.5 μmol/L, the effects of SVNs and SV on cell proliferation activity were determined (C), and massive cell death occurred in both the SVNG and the SVG as shown by an inverted microscope on the third day (B). The results are represented as the mean values of three independent measurements (±SD). *P<0.05 vs BCG; ▲P<0.05 SVNG vs SVG (0.25 μmol/L); ∆P<0.05 SVNG vs SVG (0.025 μmol/L); ♦P<0.05 SVNG vs SVG (2.5 μmol/L).

Abbreviations: BCG, blank control group; DFNG, drug-free nanomicelles group; SD, standard deviation; SV, simvastatin; SVG, simvastatin group; SVNs, simvastatin-loaded nanomicelles; SVNG, simvastatin-loaded nanomicelles group.