Table 3.
Non-compartmental mouse pharmacokinetics of TPT sulfonate.
| IV (15 mg/kg) |
PO (100 mg/kg) |
|||
|---|---|---|---|---|
| t = 0→last | t = 0→∞ | t = 0→last | t = 0→∞ | |
| C0 (ng/ml) | 37,200 | – | ||
| Cmax (ng/ml) | – | 710 | ||
| V0 (l/kg) | 0.403 | |||
| Vss (l/kg) | 0.693 | 0.984 | – | – |
| Varea (l/kg) | 7.9a | 7.7a | 7.9a | 7.7a |
| CL (ml/min/kg) | 99.6 | 97.6 | – | – |
| AUC (ng·h/ml) | 2510 | 2560 | 1430 | 1450 |
| MRT [+MIT] (h) | 0.116 | 0.168 | [1.83] | [1.94] |
| F (%) | – | – | – | 8.5 |
Abbreviations: V0, time zero volume of distribution = dose/C0; Vss, steady-state volume of distribution = CL*MRT; Varea, terminal volume of distribution = CL/terminal k; CL, plasma clearance; AUC, area under the plasma concentration-time curve; MRT, mean residence time; MIT, mean input time; F, bioavailability.
a
Based on the IV CL and the average of the k values from the last three data points of the IV and PO PK datasets (see Section 3.10).