Table 4.
Non-compartmental mouse pharmacokinetics of TPT sulfonate and its metabolites.
| Chemical species |
tmax (h) |
terminal t1/2 (h) |
AUC ratio, PO/IV |
||
|---|---|---|---|---|---|
| IV | PO | IV | PO | (normalized to dose) | |
| TPT sulfonate (m/z 290) | – | 0.50 | – | 1.3b | 0.085a |
| m/z 210 | 0.083 | 4.0 | – | 5.8b | 0.84c |
| m/z 256 | 1.0 | 2.0 | 2.2b | 2.5b | 1.49c |
| m/z 176, 0.79 min peak | 0.5 | 2.0 | 1.7b | 2.4b | 0.98c |
| m/z 176, 0.66 min peak | 0.5 | 4.0 | 1.7b | 2.3b | 1.05c |
| m/z 176, 1.25 min peak | 0.5 | 2.0 | – | 1.6b | 0.81c |
a
From WinNonlin analysis for t = 0 → ∞
b
From slope of last 3 data points of ln peak area vs. time plot, for cases with R > 0.98.
c
From AUC0-8h; mean value for metabolites is 1.03 ± 0.27.