Table 1.
Summary of the EC50 and Hill coefficient values for acetylcholine and nicotine derivatives on the C. elegans and P. equorum N-AChRs expressed in Xenopus oocytes. Results are shown as the mean ± sd. The number of eggs recorded is indicated (n).
| Cel N-AChR | Peq N-AChR | ||
|---|---|---|---|
| Acetylcholine | EC50 (μM) | 22.0 ± 1.2 | 6.4 ± 0.6 |
| Hill slope | 2.1 ± 0.4 | 2.0 ± 0.2 | |
| n | 12 | 6 | |
| Nicotine | EC50 (μM) | 15.1 ± 1.3 | 2.9 ± 0.5 |
| Hill slope | 2.2 ± 0.2 | 1.7 ± 0.2 | |
| n | 11 | 8 | |
| Nornicotine | EC50 (μM) | 67.7 ± 6.6 | 34.9 ± 7.2 |
| Hill slope | 2.7 ± 0.4 | 1.9 ± 0.3 | |
| n | 7 | 9 | |
| Anabasine | EC50 (μM) | 27.5 ± 0.9 | 1.7 ± 0.1 |
| Hill slope | 2.4 ± 0.4 | 1.8 ± 0.2 | |
| n | 14 | 6 | |