Table 2. Rate of correlated pairs over the closing process of MD2 according to their absolute Pearson correlation values over the three simulation windows: open, closing, and closed conformations.

	Window	≥0.5	≥0.6	≥0.7	≥0.8	≥0.9
HBs	Open	1 (98)	1 (53)	1 (24)	1 (10)	1 (4)
	Closing	0.64 (63)	0.55 (29)	0.54 (13)	0.7 (7)	0.25 (1)
	Closed	0.38 (37)	0.40 (21)	0.54 (13)	0.90 (9)	1.25 (5)
vdW	Open	1 (656)	1 (295)	1 (120)	1 (20)	* (0)
	Closing	0.39 (257)	0.35 (103)	0.19 (23)	0.10 (2)	* (1)
	Closed	0.12 (78)	0.08 (23)	0.07 (8)	0 (0)	* (0)

Notes:

Numbers indicate the rate between the number of correlated pairs of AAs found in the first window (open state) an the number of correlated pairs in each of the other two windows with respect to the open state for HBs and vdW interactions. In parenthesis the number of pairs of interacting AAs for each absolute Pearson correlation values.

^*Indicates the absence of an interaction in the first window so it cannot be computed for the other windows.