Table 1.
Background Characteristics of the Study Population (n = 177)
| Characteristic | Mean ± SD or n (%) |
|---|---|
| Age (years) | 55.4 ± 12.5 |
| Female | 71 (40.1) |
| Hispanic | 24 (13.6) |
| Hypertension | 81 (45.7) |
| Hypercholesterolemia | 74 (41.8) |
| Diabetes | 51 (28.8) |
| BMI (kg/m2) | 34.1 ± 6.5 |
| ALT (IU/L) | 74.8 ± 50.6 |
| Fibrosis stage | |
| 0 | 56 (31.6) |
| 1 | 39 (22) |
| 2 | 50 (28.2) |
| 3 | 18 (10.2) |
| 4 | 14 (7.9) |
| NASH | |
| Simple steatosis | 45 (25.4) |
| NASH | 132 (74.6) |
| NAS | 4.6 ± 1.5 |
| PNPLA3 | |
| CC | 66 (37.3) |
| GC | 73 (41.2) |
| GG | 38 (21.4) |
| TM6SF2 | |
| CC | 140 (79.1) |
| CT | 34 (19.2) |
| TT | 2 (1.1) |
| Genetic score* | |
| 0 | 50 (28.2) |
| 1 | 107 (60.5) |
| 2 | 20 (11.3) |
| eLP‐IR † | 67.0 ± 22.5 |
*
Genetic score of 0 assigned for those carrying neither PNPLA3 nor TM6SF2 minor alleles, 1 assigned for carrying either minor allele (regardless of heterozygosity or homozygosity), and 2 assigned for carriers of both PNPLA3 and TM6SF2 minor alleles.
†
Calculated only using fasting samples (n = 129).