Table 2.
Multivariate Analysis of the Association of eLP‐IR and Genetics With Increased NAS
| Univariate Analysis | Multivariate Analysis | |||||
|---|---|---|---|---|---|---|
| β | 95% CI | P Value | β* | 95% CI | P Value | |
| Conventional | ||||||
| Age | −0.01 | −0.03 to 0.01 | 0.16 | −0.01 | −0.02 to 0.01 | 0.4 |
| Sex (% female) | 0.57 | 0.13 to 1.0 | 0.01 | 0.4 | 0.04 to 0.8 | 0.03 |
| BMI | 0.04 | 0.002 to 0.07 | 0.03 | 0.02 | −0.01 to 0.06 | 0.12 |
| Hypertension | 0.24 | −0.19 to 0.68 | 0.27 | 0.18 | −0.25 to 0.62 | 0.41 |
| Diabetes | 0.62 | 0.16 to 1.08 | 0.01 | 0.19 | −0.27 to 0.65 | 0.41 |
| ALT (IU/L) | 0.01 | 0.005 to 0.01 | <0.001 | 0.01 | 0.002 to 0.01 | 0.004 |
| Pathogenesis based | ||||||
| eLP‐IR | 0.01 | 0.02 to 0.03 | <0.001 | 0.02 | 0.02 to 0.03 | <0.001 |
| PNPLA3 CC | REF | REF | ||||
| CG | 0.78 | 0.3 to 1.25 | 0.002 | 0.36 | −0.07 to 0.79 | 0.1 |
| GG | 0.88 | 0.3 to 1.45 | 0.003 | 0.75 | 0.24 to 1.25 | 0.004 |
| TM6SF2 CC | REF | REF | ||||
| CT or TT | 0.29 | −0.21 to 0.79 | 0.26 | 0.37 | −0.05 to 0.79 | 0.09 |
Abbreviation: REF, reference.
*
Adjusted β coefficient calculated from multivariate models with all variables in this table.