Table 7.
The Most Differentially Regulated Pathways in GnRH Neurons
| KEGG Identifier | Pathway Name | q Values | |
|---|---|---|---|
| Intact | GDX | ||
| All GnRH neurons | |||
| 4728 | Dopaminergic synapse | 1.47E-04 | 4.21E-04 |
| 4024 | cAMP signaling pathway | 1.47E-04 | 9.64E-04 |
| 4723 | Retrograde endocannabinoid signaling | 1.49E-04 | 1.00E-03 |
| 5032 | Morphine addiction | 2.07E-04 | 5.01E-04 |
| 4727 | GABAergic synapse | 3.01E-04 | 9.64E-04 |
| Intact only | |||
| 0190 | Oxidative phosphorylation | 1.96E-13 | 1.000 |
| 4260 | Cardiac muscle contraction | 8.77E-05 | 0.970 |
| 4932 | Nonalcoholic fatty liver disease | 8.77E-05 | 0.970 |
| 5010 | Alzheimer’s disease | 9.16E-05 | 0.604 |
| 5012 | Parkinson disease | 1.44E-04 | 1.000 |
| 5016 | Huntington disease | 3.01E-04 | 0.533 |
| GDX only | |||
| 4010 | MAPK signaling pathway | 0.243 | 2.63E-03 |
| 4360 | Axon guidance | 0.157 | 2.63E-03 |
| 4310 | Wnt signaling pathway | 0.053 | 6.10E-03 |
| 4931 | Insulin resistance | 0.069 | 6.15E-03 |
| 5222 | Small cell lung cancer | 0.167 | 7.03E-03 |
| Males only | Males | Females | |
| 0190 | Oxidative phosphorylation | 9.88E-07 | 0.833 |
| 4932 | Nonalcoholic fatty liver disease | 8.87E-05 | 0.492 |
| 5010 | Alzheimer’s disease | 1.23E-04 | 0.919 |
| 5012 | Parkinson disease | 1.50E-04 | 0.626 |
| 5016 | Huntington disease | 3.80E-04 | 0.513 |
| Females only | |||
| 5205 | Proteoglycans in cancer | 0.131 | 0.007 |
| 4720 | Long-term potentiation | 0.054 | 0.007 |
| 4261 | Adrenergic signaling in cardiomyocytes | 0.063 | 0.010 |
| 4918 | Thyroid hormone synthesis | 0.099 | 0.020 |
| 4015 | Rap1 signaling pathway | 0.063 | 0.026 |
Significant q values are in bold.
Abbreviations: cAMP, cyclic adenosine monophosphate; GABAergic, pertaining to γ-aminobutyric acid; MAPK, mitogen-activated protein kinase; Rap1, Ras-related protein 1.