Table 4.
Uni- and multivariate analysis of the OS (total) of 42 GBM patients
| Variables | Univariate model | Multivariate model (P<0.001) | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Sex (male) | 1.056 | 0.519–2.150 | 0.880 | 1.318 | 0.594–2.927 | 0.497 |
| Age | 1.053 | 1.015–1.092 | 0.005 | 1.058 | 1.009–1.110 | 0.020 |
| ATF5 (low) | 0.564 | 0.276–1.150 | 0.115 | 0.676 | 0.292–1.567 | 0.361 |
| No TMZ treatment | 11.010 | 3.696–32.797 | <0.001 | 6.585 | 1.917–22.623 | 0.003 |
| No radiation therapy | 1.310 | 0.306–5.600 | 0.716 | 1.687 | 0.360–7.913 | 0.507 |
| Tumor resection | ||||||
| Complete | 1.000 | Reference | 0.001 | |||
| Incomplete | 1.592 | 0.623–4.063 | 0.331 | |||
| Biopsy | 9.195 | 2.655–31.846 | <0.001 | |||
| ECOG | ||||||
| 4 | 1.000 | Reference | 0.355 | |||
| 3 | 0.306 | 0.026–3.576 | 0.345 | |||
| 2 | 1.027 | 0.092–11.487 | 0.982 | |||
| 1 | 0.342 | 0.073–1.611 | 0.175 | |||
| 0 | 0.246 | 0.052–1.160 | 0.076 | |||
| IDH wildtype | 3.942 | 0.516–30.131 | 0.186 | |||
| Ki67 staining (%) | 1.002 | 0.958–1.048 | 0.928 | |||
| Unmethylated MGMT promoter | 2.248 | 0.946–5.343 | 0.067 | |||
Notes: Uni- and multivariate analyses of the OS was performed by applying the Cox proportional hazards model. Significant values are shown in bold.
Abbreviations: ECOG, Eastern Cooperative Oncology Group scale; GBM, glioblastoma; IDH, isocitrate dehydrogenase; MGMT, O-6-methylguanine-DNA methyltransferase; OS, overall survival; TMZ, temozolomide.