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. 2018 Dec 3;12:890. doi: 10.3389/fnins.2018.00890

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Copyright © 2018 Zhang, Zhang, Gong, Zhu, Wang, Wang, Halim, Wang, Zhou and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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N-methyl-N-nitrosourea (MNU)-induced retinal function alteration was evaluated by electroretinography (ERG) recordings. The representative ERG waveforms of the normal controls and the MNU-treated retinas at different recording time points and B wave marker position shown is not what was used for quantification in this graph. (A). After MNU administration, the amplitudes of both the a- and b-waves were significantly reduced compared to those of normal controls, as determined by Kruskal–Wallis ANOVA analysis followed by post-hoc testing (B,C); ^∗∗p ≤ 0.01 for differences compared to normal controls.