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. 2018 Dec 3;12:890. doi: 10.3389/fnins.2018.00890

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Copyright © 2018 Zhang, Zhang, Gong, Zhu, Wang, Wang, Halim, Wang, Zhou and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microglia and Müller cell interaction in the retinas of rats with N-methyl-N-nitrosourea-induced retinitis pigmentosa immunohistochemical analyses in the retinal sections revealed that the Iba1-positive microglia exhibited overt ramified morphology interdigitated with glutamine synthetase-positive Müller cells with radial-oriented morphology in the inner nuclear layer (INL) before N-methyl-N-nitrosourea (MNU) injection (normal group); after MNU injection, the retinal microglia exhibited a less-ramified morphology, tended to be radially distributed across the retinal lamina to the INL and the outer nuclear layer (ONL), and were closely fasciculated with Müller cells (7-day model group). Shown are representative photomicrographs (1200 × magnification) for (A) and representative photomicrographs (400 × magnification) for (B).