Table 2.
Remaining current upon 5-s depolarization for ASD mutations A749G and G407R.
| R50 [%] | R500 [%] | R5000 [%] | n | |
|---|---|---|---|---|
| WTS | 41.1 ± 1.84 | 20.7 ± 2.05 | 13.5 ± 2.09 | 35 |
| AGS | 46.2 ± 3.92 | 11.8 ± 1.87 | 8.16 ± 1.84 | 9 |
| GRS | 73.6 ± 4.52*** | 62.6 ± 5.39*** | 59.9 ± 5.62*** | 8 |
| WTL | 69.5 ± 3.2 | 22.8 ± 2.42 | 6.12 ± 1.13 | 15 |
| AGL | 60.0 ± 4.31 | 7.22 ± 0.76### | 3.12 ± 0.56### | 6 |
| GRL | 99.2 ± 0.65### | 98.1 ± 1.33### | 80.2 ± 3.52### | 13 |
All values are presented as mean ± S.E.M. Number of independent transfections ≥2. ICa inactivation normalized to Imax was obtained 50, 500 and 5000 ms after depolarization to Vmax. Statistical analysis was performed using one-way ANOVA and Bonferroni post-hoc test. Significance ***, ### p < 0.001 in comparison to WTS (*) or WTL (#). n, number of experiments; R, remaining current; WT, wild-type. Reference data, which were already published previously, are indicated in italics (taken from reference 10).