Table 4.
Remaining current upon 5-s depolarization for APA mutations F747L and M1354I.
| R50 [%] | R500 [%] | R5000 [%] | n | |
|---|---|---|---|---|
| WTL | 71.7 ± 2.38 | 29.4 ± 2.11 | 9.83 ± 1.86 | 28 |
| FLL | 99.3 ± 0.83### | 63.4 ± 4.78### | 32.2 ± 3.52### | 10 |
| MIL | 69.9 ± 3.64 | 29.7 ± 3.81 | 16.1 ± 3.84 | 12 |
| WTS | 41.1 ± 1.84 | 20.7 ± 2.05 | 13.5 ± 2.09 | 35 |
| MIS | 44.2 ± 3.70 | 23.9 ± 3.99 | 18.4 ± 4.34 | 9 |
All values are presented as mean ± S.E.M. Number of independent transfections >3. ICa inactivation normalized to Imax was obtained 50, 500 and 5000 ms after depolarization to Vmax. Statistical analysis was performed using one-way ANOVA and Bonferroni post-hoc test (long splice variants or unpaired Student’s t-test (short splice variants). Significance ### p < 0.001 in comparison to WTL. n, number of experiments; R, remaining current; WT, wild-type.