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. 2018 Sep 10;15(1):58–77. doi: 10.1080/15548627.2018.1507439

Figure 2.

Figure 2.

Skeletal muscle growth is severely compromised in atg7Δ mice. (a) Fiber number in TA sections from WT and atg7Δ mice at P21 (n ≥ 4 per genotype). (b) MYH (red) and LAM/laminin (green) immunostaining of hind limb muscle in WT and atg7Δ embryos at E18.5; DAPI is used for nuclear staining (blue) (scale bar: 25 μm). Cross sectional area (CSA) measurement is provided (n = 3 per genotype). (c) Reduced body weight and size in atg7Δ mice compared to the WT counterpart (n ≥ 50 per genotype). (d) Analysis of muscles and organs size in atg7Δ and WT mice at P21 (QD: Quadriceps). Muscles (n ≥ 30 per genotype) and organs (n ≥ 13 per genotype) weights have been normalized to body weight. (e) Growth curve of WT and atg7Δ mice from P7 to P21 (n ≥ 13 per genotype). Values are expressed as mean ± SEM. * vs WT (* P < 0.05, ** P < 0.01, *** P < 0.001).