Table 2.
a. EPIC-Norfolk: Cardiovascular risk as a function of Lp(a) and LDL-Ccorr
b. Copenhagen City Heart Study prospective population study: Cardiovascular risk as a function of Lp(a) and LDL-Ccorr
| a | Lp(a) category | |||||||
|---|---|---|---|---|---|---|---|---|
| <80th percentile | ≥80th percentile | |||||||
| LDL-Ccorr | Mean LDL-Ccorr¶ | Median (interquartile range) Lp(a) | Hazard ratio | CVD cases / total number | Median (interquartile range) Lp(a) | Hazard ratio | CVD cases / total number | |
| LDL-Ccorr category, mmol/L | <2.5 | 2.1 | 7.7(4.8-12.7) | 1.00(reference) | 134/1,114 | 53.7(41.8-68.1) | 1.11(0.77-1.59) | 39/279 |
| 2.5 – 3.49 | 3.1 | 8.3(5.0-14.4) | 1.03(0.86-1.25) | 676/4.376 | 50.9(41.8-68.1) | 1.44(1.16-1.78)** | 229/1,182 | |
| 3.5 - 4.49 | 4.0 | 9.4(5.6-15.7) | 1.21(1.01-1.46)* | 960/4,784 | 53.1(43.7-68.1) | 1.64(1.33-2.01)*** | 296/1,187 | |
| 4.5 - 5.49 | 4.9 | 9.9(5.8-16.4) | 1.49(1.23-1.81)*** | 583/2,285 | 56.7(45.8-71.0) | 1.89(1.50-2.39)*** | 158/526 | |
| ≥5.5 | 6.1 | 11.1(6.1-18.0) | 1.61(1.29-2.00)*** | 216/762 | 56.4(46.4-79.0) | 2.17(1.58-2.98)*** | 56/159 | |
| b | Lp(a) category | |||||||
|---|---|---|---|---|---|---|---|---|
| <80th percentile | ≥80th percentile | |||||||
| LDL-Ccorr | Mean LDL-Ccorr¶ | Median (interquartile range) Lp(a) | Hazard ratio | CVD cases / total number | Median (interquartile range) Lp(a) | Hazard ratio | CVD cases / total number | |
| LDL-Ccorr category, mmol/L | <2.5 | 2.0 | 10(3.0-24) | 1.00(reference) | 201/1,358 | 95(65-123) | 1.08(0.85-1.38) | 89/453 |
| 2.5 – 3.49 | 3.0 | 12(4.1-25) | 1.08(0.92-1.26) | 638/2,608 | 83(63-120) | 1.30(1.08-1.58)** | 201/677 | |
| 3.5 - 4.49 | 4.0 | 12(4.5-25) | 1.04(0.89-1.21) | 646/2,207 | 84(63-114) | 1.50(1.24-1.83)*** | 185/503 | |
| 4.5 - 5.49 | 4.9 | 13(4.7-23) | 1.27(1.07-1.50)** | 363/997 | 71(61-110) | 1.45(1.13-1.87)** | 66/186 | |
| ≥5.5 | 6.1 | 15(5.3-27) | 1.42(1.15-1.74)*** | 153/382 | 79(63-119) | 2.34(1.63-3.35)*** | 35/77 | |
Data are presented as age-, sex-, smoking-, body mass index-, diabetes mellitus-, systolic bloodpressure-, glomerular filtration rate-adjusted hazard ratios for the 80th cohort percentile for Lp(a) with corresponding 95% confidence interval limits. LDL-Ccorr=low density lipoprotein cholesterol corrected for Lp(a) derived cholesterol (mmol/L), LDL-C = low density lipoprotein cholesterol, Lp(a) = lipoprotein(a)(mg/dL). ¶=these mean LDL-Ccorr levels apply to both Lp(a) categories, *p<=0.05, **p<0.01, ***=p-value<0.001.