Skip to main content
. Author manuscript; available in PMC: 2019 Oct 17.
Published in final edited form as: ACS Chem Neurosci. 2018 Oct 5;9(10):2484–2502. doi: 10.1021/acschemneuro.8b00415

Figure 4.

Figure 4

Synthesis of racemic 4,4’-DMAR134. i) Br2/dichloromethane, 1h at room temperature; ii) sodium diformylamide/acetonitrile, 4 h at reflux; iii) HCl/ethanol, overnight at room temperature; iv) sodium borohydride/methanol, addition over 1.5 h period; v) cyanogen bromide/anhydrous sodium acetate/methanol, 3.5 h on ice, saturated sodium carbonate; vi) potassium cyanate/water, 3 h at reflux, 2 M HCl, 2 h at reflux, saturated aqueous sodium carbonate.