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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Biomaterials. 2018 Aug 7;182:13–20. doi: 10.1016/j.biomaterials.2018.08.009

Figure 6.

Figure 6.

Summary of histological evaluation of rat knee joints exposed to different treatments following medial meniscal tear. One week after inducing the tear, the knees were intra-articularly injected with either the biolubricant (0.5 wt% or 2 wt%), saline, or Synvisc-One® and were harvested 3 weeks later for histological analysis. Effect of the biolubricant vs. saline (a, b, c and d) at two different concentrations (0.5 and 2 wt/v%). Effect of Synvisc-One® vs. saline (e, f, g and h). The differences (in percent) were standardized against the saline control. *P<0.05 vs. saline control, n=20 per group. Baseline healthy values for an animal not receiving the medial meniscal tear nor treatment via intra-articular injection for each endpoint are as follows: Substantial cartilage degeneration width (a, e), 0 μ m; total joint score (b, f), 1; osteophyte score (c, g), 1; and bone score (d, h), 0.[34]