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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: J Hypertens. 2018 Mar;36(3):510–519. doi: 10.1097/HJH.0000000000001596

Figure 5.

Figure 5

Protein kinase Cα knock out mice have reduced vascular contractility. Relaxation responses to potassium chloride (120 mmol) were performed in aorta (a) and mesenteric arteries (b) from both protein kinase C knock out and control mice. Values shown are expressed as the change in force (mN). Data are represented as mean ± SEM; n = 4. **P < 0.01, Rmax values of protein kinase C knock out vs. Control. Concentration response curves were performed to phenylephrine (10 μmol/l) in aorta (c) and mesenteric arteries (d) from both protein kinase C knock out and control mice. Values shown are expressed as the change in force (mN). (e) Concentration response curves to acetylcholine were performed in phenylephrine-precontracted aorta. Relaxation responses were calculated relative to the contraction elicited by phenylephrine. Data are represented as mean ± SEM; n = 4. **P < 0.01, Rmax values of protein kinase C knock out vs. control.