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Vascular smooth muscle responses from protein kinase Cα knock out mice are not altered compared to control. Concentration response curves to sodium nitroprusside were performed in phenylephrine (10 μmol/l)-precontracted aorta (a) and mesenteric arteries (b). Relaxation responses were calculated relative to the contraction elicited by phenylephrine. Data are represented as mean ± SEM; n = 4, Rmax values of protein kinase C knock out vs. control
