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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Curr Opin Endocr Metab Res. 2018 Feb 5;2:29–33. doi: 10.1016/j.coemr.2018.01.007

Figure 4. Proposed model for M22-initiated TSHR/IGF1R cross-talk in Graves’ orbital fibroblasts.

Figure 4

Adapted from [18]. The M22 concentration-response of hyaluronan (HA) secretion is shown on the left. Both phases of the M22 response are initiated by binding only to TSHR. Phase 1 is the high potency (low concentrations) phase and phase 2 is the low potency (high concentrations) phase. Within phase 1, M22 stimulation is dependent on IGF1 receptors (white arrows) whereas in phase 2 M22 stimulation is independent of IGF1R.