Table 2.

Selected SNPs significantly associated with PCa aggressiveness (GS ≥8 versus GS≤6 or D’Amico high versus low) and GS 4 + 3 = 7 risk.

				GS≥8 vs. GS≤6		GS 4 + 3 vs. GS 3 + 4
Gene	SNP	Location	Model	OR (95% CI)c	P value	OR (95% CI)c	P value
NFATC1	rs25656	Coding, 3ʹUTRa	REC	0.40 (0.19–0.85)	0.017	0.31 (0.15–0.62)	0.001
NFATC1	rs160189b	Intron	REC	0.44 (0.19–0.99)	0.048	0.30 (0.15–0.61)	0.001
MAP3K1	rs187899492	Intron	DOM	3.76 (1.44–9.81)	0.007	2.89 (1.42–5.88)	0.003
TRAF2	rs6560652	Intron	DOM	0.58 (0.36–0.91)	0.018	0.63 (0.45–0.88)	0.007
CD48	rs10489639	Intron	ADD	0.72 (0.53–0.97)	0.033	0.74 (0.59–0.94)	0.012
				D’Amico high vs. low		GS 4 + 3 vs. GS 3 + 4
Gene	SNP	Location	Model	OR (95% CI)d	P value	OR (95% CI)c	P value
NFATC1	rs25656	Coding, 3ʹUTRa	REC	0.51 (0.29–0.90)	0.021	0.31 (0.15–0.62)	0.001
NFATC1	rs160189a	Intron	REC	0.51 (0.28–0.91)	0.024	0.30 (0.15–0.61)	0.001
RHOA	rs11706370	Intron	REC	0.47 (0.25–0.89)	0.021	0.55 (0.30–0.99)	0.048
CASP8	rs36039030	Intron	DOM	0.30 (0.09–0.98)	0.047	0.29 (0.09–0.99)	0.048

^aLocation varied depending on transcript isoforms. Most contain synonymous SNP involving Pro662/Pro649.

Minor transcript contains either nonsynonymous SNP His>Arg at codon 634 or 3ʹUTR SNP.

^bSNP in high linkage disequilibrium (r² > 0.8) with rs25656.

^cModels adjusted for age, clinical T stage and PSA level at diagnosis.

^dModels adjusted for age and PSA level at diagnosis.