Table 3.

Selected SNPs significantly associated with aggressiveness risk in MDACC-PCa patient cohort and reclassification risk in AS cohort.

				MDACC-PCa patient cohort (N = 1762)		AS Cohort (N = 393)
				GS≥8 vs. GS≤6		Risk of reclassification
Gene name	SNP	location	Model	OR (95% CI)b	P value	HR (95% CI)d	P value
PSMB8	rs16871026	Intron	DOM	3.52 (1.40–8.84)	0.007	2.68 (1.28–5.59)	0.009
NFATC2	rs75164249	Intron	DOM	1.74 (1.06–2.85)	0.029	1.60 (1.02–2.52)	0.041
NFATC2	rs55990504a	Intron	DOM	1.68 (1.00–2.84)	0.050	1.74 (1.09–2.78)	0.020
PSMD11	rs4132610	Intron	ADD	1.34 (1.00–1.81)	0.050	1.32 (1.00–1.74)	0.047
				D’Amico high vs. low		Risk of reclassification
Gene name	SNP	location	Model	OR (95% CI)c	P value	HR (95% CI)d	P value
ITGAL	rs3087438	Intron	DOM	0.68 (0.49–0.95)	0.025	0.65 (0.45–0.95)	0.027
PIK3R1	rs34309	Intron	REC	1.63 (1.05–2.52)	0.030	1.84 (1.13–3.00)	0.014
PSMD3	rs4065321	Intron	DOM	0.69 (0.49–0.98)	0.037	0.66 (0.44–0.99)	0.045
PSMD3	rs12453334	Intron	REC	1.59 (1.00–2.51)	0.046	1.74 (1.04–2.89)	0.034

^aSNP in linkage disequilibrium (r² = 0.81) with rs75164249.

^bThe model was adjusted with age, clinical T stage and PSA levels at diagnosis.

^cThe Models adjusted for age and PSA level at diagnosis.

^dThe model was adjusted for age, GS score, clinical T stage and PSA levels at diagnosis.