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. 2018 Dec 10;13(12):e0208340. doi: 10.1371/journal.pone.0208340

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© 2018 De Meulenaere et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — a. Static whole-body rat [¹⁸F]FDG PET image. b. Static whole-body rat [¹⁸F]NaF PET image. c. PET-CT image of rat vertebra; [¹⁸F]FDG PET image anatomically correlated with high resolution CT (recon: FDK—50 μm). This lytic lesion is clearly visible on the [¹⁸F]FDG PET images as a hypermetabolic lesion (‘hot spot’) d. PET-CT image of rat vertebra; [¹⁸F]NaF PET image anatomically correlated with high resolution CT (recon: FDK—50 μm). The bone lesions have a mixed appearance: both ‘hot spots’ and ‘cold spots’ are visualized in the lytic CT lesions, probably depending on the stage of destruction and reaction of the surrounding bone.