Table 1.
Characteristics at study entry in participants who did or did not develop incident AF
| Characteristic | Incident AF, n=323 | No Incident AF, n=2757 | P Value |
|---|---|---|---|
| Age, mean (SD), yr | 61.6 (9.2) | 57.3 (11.2) | <0.001 |
| Women, N (%) | 129 (39.9) | 1258 (45.6) | 0.05 |
| Race/ethnicity, N (%) | |||
| Non-Hispanic white | 165 (51.1) | 1156 (41.9) | 0.009 |
| Non-Hispanic black | 119 (36.8) | 1120 (40.6) | |
| Hispanic | 30 (9.3) | 365 (13.2) | |
| Other | 9 (2.8) | 116 (4.2) | |
| Diabetes mellitus, N (%) | 171 (52.9) | 1290 (46.8) | 0.04 |
| Hypertension, N (%) | 298 (92.3) | 2341 (84.9) | <0.001 |
| Prior MI or coronary revascularization, N (%) | 103 (31.9) | 449 (16.3) | <0.001 |
| History of stroke, N (%) | 36 (11.1) | 231 (8.4) | 0.10 |
| History of HF, N (%) | 38 (11.8) | 145 (5.3) | <0.001 |
| History of peripheral vascular disease, N (%) | 24 (7.4) | 158 (5.7) | 0.22 |
| Any prior CVD, N (%) | 143 (44.3) | 723 (26.2) | <0.001 |
| Current smoker, N (%) | 41 (12.7) | 361 (13.1) | 0.84 |
| Systolic BP, mean (SD), mm Hg | 131.9 (21.9) | 127.7 (21.7) | 0.001 |
| BMI, mean (SD), kg/m2 | 33.0 (7.9) | 31.8 (7.7) | 0.01 |
| eGFR, ml/min per 1.73 m2, N (%) | |||
| <30 | 78 (24.1) | 514 (18.6) | <0.001 |
| 30–44 | 127 (39.3) | 885 (32.1) | |
| 45–59 | 81 (25.1) | 814 (29.5) | |
| ≥60 | 37 (11.5) | 544 (19.7) | |
| Urine protein, median (IQR), g/24 h | 0.2 (0.1–0.9) | 0.2 (0.1–1.0) | 0.27 |
| Aspirin use, N (%) | 167 (51.7) | 1130 (41.0) | <0.001 |
| Antiplatelet use, N (%) | 177 (54.8) | 1212 (44.0) | <0.001 |
| Warfarin use, N (%) | 20 (6.2) | 59 (2.1) | <0.001 |
| FGF23, median (IQR), RU/ml | 163.7 (109.2–255.0) | 135.5 (91.7–219.3) | <0.001 |
| hs-CRP, median (IQR), mg/L | 3.4 (1.3–7.6) | 2.4 (1.0–5.9) | <0.001 |
| NT-proBNP, median (IQR), pg/ml | 326.7 (120.2–678.2) | 120.2 (53.8–291.6) | <0.001 |
| hsTnT, median (IQR), pg/ml ECG parameters | 16.5 (9.1–32.5) | 10.7 (5.1–20.9) | <0.001 |
| Left ventricular hypertrophy, N (%) | 158 (65.3) | 969 (47.4) | <0.001 |
| Left ventricular mass index, median (IQR), g/m2 | 55.4 (46.7–64.3) | 47.8 (40.7–57.3) | <0.001 |
| Left atrial diameter, mean (SD), cm | 4.1 (0.7) | 3.9 (0.6) | <0.001 |
| Left ventricular ejection fraction, median (IQR) | 54.5 (49.0–57.8) | 55.5 (51.9–59.3) | <0.001 |
IQR, interquartile range.