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Changes in serum creatinine levels associated with international normalized ratio (INR) increase ≥3.0 in patients whose initial serum creatinine change was either ≥0.3 mg/dl (upper curve) or <0.3 mg/dl (lower curve). In patients with CKD, 33% developed AKI. In patients with no CKD, 16.5% developed AKI.2 For the cohort as a whole, 20.5% developed AKI. WRN, warfarin-related nephropathy.
