Fig 6. Ribotides and ribosides detected in cell lysates of ADSL-deficient and control HeLa cells.

The deficient cell line is graphically represented by a PDNS pathway with an enzyme block marked by a red rectangle. Accumulating metabolites are marked with red bold letters with an arrow. Cell lines were measured in hexaplicate, and the value of the unlabeled peak intensity given above the baseline represents the average of a particular metabolite. Chromatographic peaks of metabolites that were detected also in labeled form are shown as an asterisk. Note: The ionization efficiency of ribotides and ribosides is substantially different, so the responses of these compounds are not directly comparable.