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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Pain. 2018 Feb;159(2):224–238. doi: 10.1097/j.pain.0000000000001106

Figure 4. Fingolimod prevents the EAE-induced potentiation of glutamate-evoked Ca2+ signaling.

Figure 4.

(A) Concentration-dependence of glutamate-evoked Ca2+ responses in dorsal horn slices from MOG35–55-treated and sham mice. Calcium level (expressed as ΔF340/F380 as a function of increasing glutamate concentration. (B) Glutamate-evoked Ca2+ responses in EAE mice treated with vehicle or fingolimod (1 mg/kg for 7–10 days). Data represent mean ± SEM. N = 7 in vehicle groups, 8 in MOG35–55 + fingolimod group and 9 in MOG35–55 and sham group. *P<0.05, **P<0.01.