Table 1.
50 NAc proteins altered by both ENT1 genotype and acamprosate treatment.
| Protein Name | Gene | KO vs. WT | KO vs. KO | WT vs. WT | |||
|---|---|---|---|---|---|---|---|
| Con vs. Con | Acam vs. Con | Acam vs. Con | |||||
| Ratio | p-value | Ratio | p-value | Ratio | p-value | ||
| Myc box-dependent-interacting protein 1 | BIN1_MOUSE | 1.316 | 8.43E-09 | 0.799 | 0.004 | 1.29 | 6.16E-07 |
| Diacylglycerol kinase beta | DGKB_MOUSE | 1.789 | 1.68E-08 | 0.71 | 7.05E-04 | 1.502 | 7.33E-05 |
| Rabphilin-3A | Q768S5_MOUSE | 1.838 | 2.13E-07 | 0.721 | 0.008 | 1.684 | 3.51E-06 |
| MKIAA1758 protein | B9EJA2_MOUSE | 1.548 | 1.92E-06 | 0.748 | 0.007 | 1.295 | 0.047 |
| Msn protein | MOES_MOUSE | 1.456 | 2.61E-06 | 0.828 | 0.002 | 1.354 | 9.80E-04 |
| Wiskott-Aldrich syndrome protein family member 1 | WASF1_MOUSE | 1.744 | 3.87E-06 | 0.759 | 0.012 | 1.61 | 1.88E-04 |
| Ezrin | EZRI_MOUSE | 1.879 | 7.97E-06 | 0.768 | 0.033 | 1.733 | 0.001 |
| Putative uncharacterized protein | Q8C605_MOUSE | 1.391 | 1.16E-05 | 0.802 | 1.20E-04 | 1.351 | 0.002 |
| Q6P1J1_MOUSE Crmp1 protein | Q6P1J1_MOUSE | 1.743 | 4.31E-05 | 0.802 | 0.049 | 1.729 | 0.002 |
| Isoform 2 of Dynamin-like 120 kDa protein | OPA1_MOUSE_2 | 1.28 | 1.01E-04 | 0.849 | 0.017 | 1.282 | 0.007 |
| Phosphofructokinase | Q8VDX7_MOUSE | 1.304 | 1.33E-04 | 0.837 | 0.003 | 1.307 | 1.92E-04 |
| Hypoxanthine guanine phosphoribosyl transferase 1 | B1B0W8_MOUSE | 0.812 | 2.07E-04 | 1.154 | 0.017 | 0.735 | 2.95E-05 |
| Adenylyl cyclase-associated protein | CAP1_MOUSE | 0.206 | 2.66E-04 | 4.267 | 0.03 | 0.389 | 0.029 |
| Glial high affinity glutamate transporter | EAA2_MOUSE | 1.109 | 2.79E-04 | 0.914 | 0.004 | 1.125 | 0.018 |
| LETM1 and EF-hand domain-containing protein 1 | LETM1_MOUSE | 1.188 | 3.36E-04 | 0.671 | 9.93E-11 | 1.168 | 0.005 |
| Dynein cytoplasmic 1 intermediate chain 2 | D6Q0F5_MOUSE | 1.32 | 3.51E-04 | 0.785 | 0.008 | 1.344 | 0.001 |
| Protein kinase C epsilon type | B1B1C8_MOUSE | 1.379 | 3.60E-04 | 0.855 | 0.045 | 1.388 | 0.013 |
| Calnexin | CALX_MOUSE | 1.371 | 6.20E-04 | 0.749 | 0.002 | 1.332 | 0.004 |
| Aconitate hydratase, mitochondrial | ACON_MOUSE | 1.336 | 6.66E-04 | 0.678 | 6.31E-05 | 1.228 | 0.009 |
| Rab15 | Q3TYH2_MOUSE | 0.668 | 0.002 | 1.21 | 0.009 | 0.722 | 0.029 |
| Thimet oligopeptidase | THOP1_MOUSE | 1.296 | 0.002 | 0.85 | 0.014 | 1.301 | 0.018 |
| 14–3-3 protein theta | 1433T_MOUSE | 0.898 | 0.002 | 1.088 | 0.025 | 0.834 | 5.97E-04 |
| cGMP 3’,5’-cyclic phosphodiesterase 10A | PDE10_MOUSE | 1.357 | 0.003 | 0.734 | 4.51E-04 | 1.189 | 0.041 |
| Adenylate cyclase type 5 | ADCY5_MOUSE | 1.149 | 0.003 | 0.836 | 8.99E-04 | 1.174 | 0.022 |
| Rap1 GTPase-activating protein | A2ALS7_MOUSE | 1.227 | 0.003 | 0.816 | 0.006 | 1.263 | 0.002 |
| Receptor-type tyrosine-protein phosphatase delta | PTPRD_MOUSE | 1.319 | 0.003 | 0.842 | 0.037 | 1.349 | 0.01 |
| Tubulin polymerization-promoting protein | Q3URG1_MOUSE | 0.777 | 0.004 | 1.43 | 0.001 | 0.846 | 0.007 |
| Synapsin-1 | SYN1_MOUSE | 1.238 | 0.004 | 0.787 | 0.001 | 1.218 | 0.007 |
| Phosphatidylinositol-4-phosphate 5-kinase gamma | PI51C_MOUSE | 1.15 | 0.004 | 0.857 | 0.006 | 1.153 | 0.007 |
| Rapgef2 protein | Q6NXI4_MOUSE | 1.146 | 0.007 | 0.903 | 0.035 | 1.366 | 9.48E-10 |
| Putative uncharacterized protein | DNM1L_MOUSE | 1.29 | 0.008 | 0.752 | 1.54E-05 | 1.233 | 0.042 |
| 14–3-3 protein gamma | 1433G_MOUSE | 0.914 | 0.009 | 1.162 | 0.002 | 0.861 | 0.005 |
| 6-phosphofructokinase, muscle type | K6PF_MOUSE | 1.289 | 0.01 | 0.823 | 0.015 | 1.298 | 0.005 |
| Dihydropteridine reductase | DHPR_MOUSE | 0.879 | 0.01 | 1.128 | 0.031 | 0.824 | 0.022 |
| Putative uncharacterized protein | Q99JZ4_MOUSE | 0.787 | 0.012 | 0.748 | 0.001 | 0.559 | 1.27E-06 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L1 | UCHL1_MOUSE | 0.832 | 0.012 | 1.213 | 0.011 | 0.757 | 2.87E-05 |
| Cullin 5 | CUL5_MOUSE | 1.292 | 0.015 | 0.804 | 0.04 | 1.32 | 0.006 |
| Uncharacterized protein C6orf174 homolog | CF174_MOUSE | 1.335 | 0.015 | 0.809 | 0.045 | 1.314 | 0.019 |
| Rho GDP-dissociation inhibitor 1 | GDIR1_MOUSE | 0.872 | 0.017 | 1.206 | 0.003 | 0.863 | 0.017 |
| Putative uncharacterized protein | CUL1_MOUSE | 1.277 | 0.019 | 0.79 | 0.003 | 1.298 | 0.007 |
| MKIAA0617 protein | Q6ZQ84_MOUSE | 1.295 | 0.021 | 0.788 | 0.018 | 1.273 | 0.013 |
| Vesicle-associated membrane protein B | VAPB_MOUSE | 0.861 | 0.021 | 1.136 | 0.019 | 0.784 | 0.004 |
| AMP phosphotransferase, mitochondrial | KAD3_MOUSE | 0.859 | 0.023 | 1.204 | 0.01 | 0.841 | 0.003 |
| Platelet-activating factor acetylhydrolase IB subunit | PA1B2_MOUSE | 0.896 | 0.031 | 1.137 | 0.015 | 0.822 | 0.003 |
| Tubulin alpha-4A chain | TBA4A_MOUSE | 0.885 | 0.031 | 0.737 | 0.029 | 0.623 | 5.69E-10 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L3 | UCHL3_MOUSE | 0.864 | 0.035 | 1.2 | 0.024 | 0.826 | 0.025 |
| Myosin-9 | MYH9_MOUSE | 1.214 | 0.039 | 0.601 | 1.00E-04 | 1.427 | 2.46E-07 |
| HECT, UBA and WWE domain containing 1 | Q4JG03_MOUSE | 0.785 | 0.042 | 0.829 | 0.004 | 0.686 | 0.011 |
| Protein kinase C and casein kinase substrate | PACN2_MOUSE | 1.39 | 0.044 | 0.631 | 0.02 | 1.382 | 0.015 |
| Triosephosphate isomerase | TPIS_MOUSE | 0.872 | 0.05 | 1.251 | 0.004 | 0.863 | 0.003 |
*
p < 0.05 compared with control treatment by unpaired two-tailed t-test.