Table 5.
Biological variation for marker concentrations (μM) in the NHP 7-day urine samples. The technical variation is generally on the order of 5% or less. Misclassified samples in Table 4 are “2007” and “4006”. Limited 10 Gy sample was exhausted before creatinine measurements, so values are note given.
| Concentrationby NHP | Name | creatine | hypoxanthine | TML | isobutyrylcarnitine | xanthine | xanthurenic acid | creatinine |
|---|---|---|---|---|---|---|---|---|
| ----------------------------------------- μM ----------------------------------------- | mM | |||||||
| Control | C1 | 420.3 | 113.7 | 121.3 | 43.2 | 224.5 | 47.5 | 43.4 |
| C2 | 668.4 | 114.3 | 80.6 | 11.8 | 201.3 | 58.5 | 19.5 | |
| C3 | 213.8 | 169.9 | 94.5 | 40.8 | 104.0 | 30.9 | 18.6 | |
| 2 Gy | 2005 | 159.4 | 201.0 | 48.9 | 37.7 | 247.8 | 46.6 | 14.7 |
| 2006 | 100.5 | 180.0 | 24.1 | 36.0 | 193.7 | 51.4 | 14.9 | |
| 2007 | 174.3 | 76.8 | 79.2 | 30.5 | 229.7 | 66.3 | 18.1 | |
| 4 Gy | 3005 | 208.7 | 137.3 | 41.6 | 66.4 | 136.3 | 41.3 | 20.0 |
| 3006 | 161.6 | 81.5 | 45.0 | 29.4 | 162.8 | 70.9 | 12.5 | |
| 3008 | 566.2 | 36.3 | 211.2 | 22.2 | 278.6 | 65.9 | 26.3 | |
| 6 Gy | 4004 | 2455.2 | 45.6 | 54.3 | 28.2 | 97.4 | 81.9 | 11.6 |
| 4005 | 364.0 | 114.8 | 20.5 | 18.7 | 136.4 | 66.2 | 8.9 | |
| 4006 | 157.2 | 196.4 | 36.1 | 47.7 | 257.5 | 88.7 | 13.3 | |
| 7 Gy | 5006 | 4651.7 | 155.9 | 189.0 | 33.1 | 346.5 | 89.2 | 15.3 |
| 5007 | 4594.6 | 158.7 | 2890.8 | 6.6 | 693.9 | 329.3 | 33.4 | |
| 5008 | 349.6 | 89.5 | 1551.1 | 2.0 | 119.6 | 112.3 | 11.3 | |
| 10 Gy | 6007 | 8972.9 | 98.6 | 1317.4 | 2.6 | 410.9 | 187.8 | – |
| 6008 | 7337.1 | 184.5 | 1069.0 | −1.0 | 529.4 | 279.9 | – | |