Figure 1. Construction of the WLMT clock.

(A) Datasets used for the clock construction and initial validation. Radii of pie charts correspond to the number of samples in a group. The range of ages is shown above (in months). Performance of the whole-lifespan multi-tissue clock on training (B) and test (C) sets. MAE on training and test sets was 28.6 and 72.7 days, respectively. Tissues used are indicated on the right according to the color scheme.

Figure 1—figure supplement 1. Density plot for the number of CpG sites covered in all samples.

(A) and in samples with covered ${\displaystyle 2÷7\cdot {10}^6}$ sites, which were used to train the WLMT clock (B).

Figure 1—figure supplement 2. Principle component analysis of samples sequenced in the study.

Library ‘M20’ was not used in the preparation of the clock.

Figure 1—figure supplement 3. Performance of the WLMT clock on male (blue) and female (pink) samples.

Figure 1—figure supplement 4. Number of reads obtained for the sequenced samples.