Figure 2.

Comparison of Human Chromosome 21 and Mouse Models

(A) Genes in human chromosome 21 have orthologous regions on three mouse chromosomes.

(B) Schematic of chromosome 21 genes that are represented in three mouse models: Ts65Dn (the most widely studied mouse model), Dp16, and Tc1 (a transchromosomic mouse line).^{118, 119, 120}