Table 4. Prognostic application of the pretreatment ADC in primary head and neck SCC lesion.
| Study | T | b values (s/mm2) | Main findings |
|---|---|---|---|
| Chawla et al. (68) | 1.5 | 0, 500, 1,000 | Higher ADC values in non-responders |
| Hatakenaka et al. (63) | 1.5 | 0, 100, 200, 300, 500, 750, 1,000 | High ADC (and tumor volume) correlate with local failure after radiotherapy |
| Kim et al. (62) | 1.5/3 | 0, 500, 1,000 | Higher ADC value in partial responders compared to complete responders |
| King et al. (67) | 1.5 | 0, 100, 200, 300, 400, 500 | Pretreatment ADC parameters showed no correlation with local failure |
| Lambrecht et al. (65) | 1.5 | 0, 50, 100, 500, 750, 1,000 | ADC value from high b-values (500–1,000) independent prognostic factor |
| Nakajo et al. (69) | 1.5 | 0, 800 | Low ADC predictive of poor 2-year disease free survival |
| Ng et al. (66) | 3 | 0, 800 | High ADC value was poor prognostic factor for 3-year focal control rate |
| Ohnishi et al. (64) | 1.5 | 0, 300, 1,000 | High ADC values in patients with lower local control |
| Srinivasan et al. (70) | 3 | 0, 800 | Lower ADC associated with better outcome at 2 years |
T, magnet field strength in Tesla; SCC, squamous cell carcinoma; ADC, apparent diffusion coefficient.