Table 4. Associations between ROIs in structural MRI and cognitive decline at 24-month.

Regions	Coefficience/P value	CDRSB	ADAS 13	FAQ	MOCA	MMSE	ADNI-MEM	RAVLT-immediate	RAVLT-perc-forgetting	EcogSPVisspat	EcogSPPlan	EcogSTotal	ADNI-EF
Subcortical volume of right inferior lateral ventricle	β	0.001	0.003	0.002	−0.001	−0.002	0	−0.001	0.008	0	0	0	0
	P	0.001*	0.023*	0.013*	0.164	<0.001**	0.408	0.212	0.055	0.001*	0.003*	<0.001**	0.307
Cortical volume of left isthmus cingulate	β	−0.001	−0.003	−0.003	0.001	0	0	0.002	−0.005	0	0	0	0
	P	0.009*	0.024*	0.008*	0.485	0.611	0.019*	0.319	0.417	0.035*	0.153	0.119	0.412
Subcortical volume of corpus callosum central	β	−0.004	−0.013	−0.02	0	0.004	0.001	0.002	0.008	−0.003	−0.004	−0.003	0.001
	P	0.076	0.08	0.003*	0.926	0.22	0.174	0.816	0.82	0.003*	<0.001**	<0.001**	0.452
Cortical volume of left middle temporal	β	0	−0.002	−0.001	0.001	0.001	0	0.002	−0.001	0	0	0	0
	P	0.002*	<0.001**	<0.001**	0.003*	0.003*	<0.001**	<0.001**	0.697	<0.001**	0.009*	<0.001**	0.003*
Thickness average of left middle temporal	β	−2.437	−9.875	−9.994	5.283	5.183	0.787	10.29	−10.938	−1.127	−0.977	−0.832	0.621
	P	0.001*	<0.001**	<0.001**	<0.001**	<0.001**	<0.001**	<0.001**	0.355	<0.001**	0.003*	<0.001**	0.02*
Surface area of left posterior cingulate	β	−0.002	−0.008	−0.009	0.001	0.001	0.001	0.005	−0.013	−0.001	−0.001	−0.001	0.001
	P	0.013*	0.013*	0.003*	0.38	0.639	0.01*	0.214	0.381	0.007*	0.084	0.026*	0.013*
Thickness standard deviation of left rostral anterior cingulate	β	2.824	1.097	6.592	−1.847	−2.981	−0.2	−0.997	28.055	0.781	1.208	0.771	−0.011
	P	0.009*	0.764	0.036*	0.315	0.064	0.431	0.809	0.082	0.062	0.007*	0.024*	0.976
Cortical volume of left superior temporal	β	0	−0.001	−0.001	0	0	0	0.001	0.002	0	0	0	0
	P	0.06	0.054	0.003*	0.405	0.416	0.006*	0.005*	0.363	0.01*	0.104	0.038*	0.3
Thickness average of left superior temporal	β	−2.687	−6.139	−8.349	3.615	3.796	0.764	12.287	−9.525	−0.824	−0.839	−0.635	0.441
	P	<0.001**	0.022*	<0.001**	0.008*	0.001*	<0.001**	<0.001**	0.434	0.008*	0.015*	0.014*	0.108
Thickness average of right isthmus cingulate	β	−2.402	−5.956	−5.322	3.569	3.251	0.375	3.607	8.392	−0.458	−0.359	−0.511	0.482
	P	<0.001**	0.005*	0.005*	<0.001**	<0.001**	0.015*	0.14	0.386	0.071	0.195	0.014*	0.027*
Subcortical volume of right amygdala	β	−0.003	−0.01	−0.01	0.003	0.004	0.001	0.009	−0.016	−0.001	−0.001	−0.001	0.001
	P	<0.001**	<0.001**	<0.001**	0.008*	<0.001**	<0.001**	<0.001**	0.109	<0.001**	0.046*	0.005*	0.017*
Subcortical volume of left amygdala	β	−0.003	−0.011	−0.01	0.004	0.004	0.001	0.009	−0.016	−0.001	0	−0.001	0
	P	<0.001**	<0.001**	<0.001**	0.001*	<0.001**	<0.001**	<0.001**	0.118	<0.001**	0.096	0.003*	0.04*
Subcortical volume of right hippocampus	β	−0.001	−0.004	−0.005	0.001	0.002	0	0.003	−0.01	−0.001	0	0	0
	P	<0.001**	<0.001**	<0.001**	0.039*	<0.001**	<0.001**	0.002*	0.03*	<0.001**	0.008*	<0.001**	0.09
Subcortical volume of left hippocampus	β	−0.001	−0.005	−0.004	0.001	0.002	0	0.004	−0.006	0	0	0	0
	P	<0.001**	<0.001**	<0.001**	0.021*	<0.001**	<0.001**	<0.001**	0.182	<0.001**	0.063	0.009*	0.051
Cortical volume of left entorhinal	β	−0.001	−0.004	−0.003	0.001	0.002	0	0.004	−0.002	0	0	0	0
	P	0.007*	0.005*	0.006*	0.044*	<0.001**	<0.001**	0.002*	0.692	0.07	0.573	0.272	0.919
Cortical volume of right entorhinal	β	−0.001	−0.004	−0.005	0.002	0.002	0	0.004	−0.002	0	0	0	0
	P	<0.001**	0.003*	<0.001**	0.002*	<0.001**	<0.001**	0.004*	0.697	0.005*	0.059	0.013*	0.014*
Thickness average of left entorhinal	β	−1.368	−4.072	−3.508	1.697	1.946	0.369	5.438	−4.859	−0.326	−0.229	−0.245	0.176
	P	<0.001**	<0.001**	<0.001**	0.001*	<0.001**	<0.001**	<0.001**	0.302	0.008*	0.09	0.016*	0.097
Thickness average of right entorhinal	β	−1.385	−3.543	−3.683	1.58	2.067	0.283	3.762	−3.987	−0.275	−0.191	−0.216	0.181
	P	<0.001**	<0.001**	<0.001**	0.002*	<0.001**	<0.001**	<0.001**	0.382	0.024*	0.146	0.028*	0.081

B, regression coefficient. *, P<0.05; **, P<0.001.