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. 2018 Nov 26;221(23):jeb185504. doi: 10.1242/jeb.185504

Fig. 2.

Fig. 2.

Acute LPS blocks the kisspeptin-induced increase in testosterone but not luteinizing hormone (LH). (A) Effects of LPS and kisspeptin (Kiss) injection on body temperature. LPS-treated animals did not experience significant rises in body temperature after injection. (B) All groups experienced increases in serum cortisol throughout the experiment. (C) Animals injected with kisspeptin experienced increases in serum LH, regardless of LPS treatment. (D) However, LPS blocked the kisspeptin-induced increase in testosterone. These results were replicated in experiment 2. Boxes denote the boundaries of the second and third quartiles with Tukey whiskers. Asterisks denote significant differences between pre- and post-injection time points. Significance was set at P<0.05 (**P<0.01, ***P<0.001). Plus signs indicate the group mean, while circles and squares represent individual values falling outside 1.5 times the interquartile range of the distribution of the pre- or post-injection time points. Letters denote differences between groups at the post-injection time point. Saline+PBS, n=9; LPS+PBS, n=10; saline+kisspeptin, n=9; LPS+kisspeptin, n=10. Group sizes for the cortisol graph in B (because of missing values): saline+PBS, n=8; LPS+PBS, n=9; saline+kisspeptin, n=7; LPS+kisspeptin, n=10.